Depth moderates loss of marine foundation species after an extreme marine heatwave: could deep temperate reefs act as a refuge? [PDF]
Proc Biol Sci, 2020 Giraldo-Ospina A, Kendrick GA, Hovey RK.
europepmc +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Limited life-history plasticity in marginal population of an invasive foundation species: Unraveling the genetic underpinnings and ecological implications. [PDF]
Ecol EvolChen X, Wang J, Liu W, Zhang Y.
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Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
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Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
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Population re-establishment and spatial dynamics of crowberry (<i>Empetrum nigrum</i> ssp. <i>hermaphroditum</i>), a foundation species in restored alpine ecosystems. [PDF]
Ecol EvolSulavik J +4 more
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Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Climate Change Impacts on Marine Foundation Species
Marine foundation species are vital to coastal ecosystems, offering structural habitat, nourishment, and shelter to a variety of plants and animals, as well as supporting a range of ecosystem services. Climate change seriously threatens foundation species and the ecosystems they sustain.
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Determinants of temperature sensitivity of soil respiration with the decline of a foundation species. [PDF]
PLoS One, 2019 Ignace DD.
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