Results 31 to 40 of about 7,919 (306)

Le concept d’espace chez Veronese

Philosophia Scientiæ, 2009
Giuseppe Veronese is known for his studies on spaces with more dimensions; less known are his “philosophical” writings, that concern the foundations of geometry and mathematics and explain the reasons for constructing a non-Archimedean geometry (several ...
Paola Cantù
doaj   +1 more source

Axial Bearing Mechanism of Post-Grouted Piles in Calcareous Sand

Applied Sciences, 2022
Post-grouted piles, as a foundation form for large-span and large-scale structures on calcareous sand, are expected to provide a high bearing capacity, but research on the response of post-grouted piles subjected to axial load in calcareous sand is still
Zhihui Wan, Heng Liu, Feng Zhou, Guoliang Dai   +3 more
doaj   +1 more source

Foundations of Geometry – I

Kathmandu University Journal of Science, Engineering and Technology, 1970
N ...
openaire   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The Geometry of Noncommutative Spacetimes

Universe, 2017
We review the concept of ‘noncommutative spacetime’ approached from an operational stand-point and explain how to endow it with suitable geometrical structures. The latter involves i.a.
Michał Eckstein
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Prediction of Ultimate Bearing Capacity of Shallow Foundations on Cohesionless Soils: A Gaussian Process Regression Approach

Applied Sciences, 2021
This study examines the potential of the soft computing technique—namely, Gaussian process regression (GPR), to predict the ultimate bearing capacity (UBC) of cohesionless soils beneath shallow foundations. The inputs of the model are width of footing (B)
Mahmood Ahmad, Feezan Ahmad, Piotr Wróblewski, Ramez A. Al-Mansob, Piotr Olczak, Paweł Kamiński, Muhammad Safdar, Partab Rai   +7 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source