Results 41 to 50 of about 7,919 (306)

Euclid's and Hilbert's foundations of geometry

Le Matematiche, 2000
The purpose of this note is to substantiate and explain the following quote from Hilbert.
Benno Artmann
doaj  

A MODULI STACK OF TROPICAL CURVES

Forum of Mathematics, Sigma, 2020
We contribute to the foundations of tropical geometry with a view toward formulating tropical moduli problems, and with the moduli space of curves as our main example.
RENZO CAVALIERI, MELODY CHAN, MARTIN ULIRSCH, JONATHAN WISE   +3 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Research on the bearing mechanism and structural design method of embedded foundations for transmission towers under slope conditions

Frontiers in Earth Science
IntroductionEmbedded foundations, prized for their high bearing capacity and compact footprint, are a prevalent and innovative solution for transmission tower support.
Mingyi Wang, Mingyi Wang, Yongqiang Zhou, Yongqiang Zhou, Zihua Chen, Cunguo Wang, Xinguo Wang, Aiguo Yan, Zhihui Zhang, Zhihui Zhang, Xiaodong Fu, Xiaodong Fu   +11 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Poznanie geometryczne z kognitywnego punktu widzenia

Zagadnienia Filozoficzne w Nauce, 2021
This review discusses the content of Mateusz Hohol’s new book Foundations of Geometric Cognition. Mathematical cognition has until now focused mainly on human numerical abilities.
Jerzy Pogonowski
doaj  

A new design equation for prediction of ultimate bearing capacity of shallow foundation on granular soils

Journal of Civil Engineering and Management, 2014
A major concern in design of structures is to provide precise estimations of ultimate bearing capacity of soil beneath their foundations. Direct determination of the bearing capacity of foundations requires performing expensive and time consuming ...
Ehsan Sadrossadat, Fazlollah Soltani, Seyyed Mohammad Mousavi, Seyed Morteza Marandi, Amir H. Alavi   +4 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source