Results 81 to 90 of about 12,894 (297)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher   +10 more
wiley   +1 more source

Stabilization of Stochastic Dynamic Systems with Markov Parameters and Concentration Point

open access: yesMathematics
This paper addresses the problem of optimal stabilization for stochastic dynamical systems characterized by Markov switches and concentration points of jumps, which is a scenario not adequately covered by classical stability conditions.
Taras Lukashiv   +3 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown   +6 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen   +7 more
wiley   +1 more source

Advanced Manifold–Metric Pairs

open access: yesMathematics
This article presents a novel mathematical formalism for advanced manifold–metric pairs, enhancing the frameworks of geometry and topology. We construct various D-dimensional manifolds and their associated metric spaces using functional methods, with a ...
Pierros Ntelis
doaj   +1 more source

PROBLEM OF THE DEFINITION THE «RELIABILITY» TERM. METHODOLOGY OF CONSTRUCTION AND STUDY THE RELIABILITY OF FREIGHT CARS

open access: yesNauka ta progres transportu, 2015
Purpose. Scientific paper is aimed at disclosing the existing problem of the «reliability» definition and provides a reasoned definition of the term. The study assumes the development of a complex that includes the methodology and appropriate terminology
S. V. Myamlin   +2 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

MODEL OF PROFESSIONAL ORIENTED EDUCATION OF FUTURE ENGINEERS PROBABILITY THEORY AND STOCHASTIC PROCESSES AND ITS IMPLEMENTATION WHEN PRACTICAL LESSONS

open access: yesÌнформаційні технології в освіті, 2014
The concept model and various approaches to creating of such models are analyzed in the paper. The essence of the model which reflects the process of implementing all the components of designed teaching methodology in their interaction is presented ...
E. Chumak
doaj  

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