Results 41 to 50 of about 8,586,817 (317)
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Hypothetical Unification of the Four Forces, Information, Light and Gravity
, 2023 How QIH Unifies Quantum Mechanics, Relativity, Light and the 4 forces. In normal and detailed terms. The Universe's Decoder Ring: Imagine the universe as an intricate puzzle. To solve it, you might need a decoder ring that reveals hidden patterns. In this context, we have an equation that acts like this decoder ring, helping us understand the universe ...
openaire +2 more sources
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
FEBS Letters, EarlyView.The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke +2 more
wiley +1 more source
The String landscape, black holes and gravity as the weakest force [PDF]
, 2006 We conjecture a general upper bound on the strength of gravity relative to gauge forces in quantum gravity. This implies, in particular, that in a four-dimensional theory with gravity and a U(1) gauge field with gauge coupling g, there is a new ...
N. Arkani-Hamed +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
A General Relativistic Rotating Evolutionary Universe
, 2008 We show that when we work with coordinate cosmic time, which is not proper time, Robertson-Walker's metric, includes a possible rotational state of the Universe. An exact formula for the angular speed and the temporal metric coefficient, is found.Comment:
C. Brans +7 more
core +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Anatomy of the energetic driving force for charge generation in organic solar cells
Nature Communications, 2019 Eliminating the excess energetic driving force in organic solar cells leads to a smaller energy loss and higher device performance; hence, it is vital to understand the relation between the interfacial energetics and the photoelectric conversion ...
Kyohei Nakano +7 more
semanticscholar +1 more source
Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins
bioRxiv, 2020 Mitotic spindle microtubules (MTs) undergo continuous poleward flux, whose driving force and function in humans remain unclear. Here, we combined loss-of-function screenings with analysis of MT dynamics in human cells to investigate the molecular ...
Yulia Steblyanko +8 more
semanticscholar +1 more source