Results 51 to 60 of about 8,586,817 (317)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Modeling DNA Flexibility: Comparison of Force Fields from Atomistic to Multiscale Levels.

Journal of Physical Chemistry B, 2019
Accurate parameterization of force fields (FF) is of ultimate importance for computer simulations to be reliable and to possess a predictive power.
Vishal Minhas, Tiedong Sun, A. Mirzoev, N. Korolev, A. Lyubartsev, L. Nordenskiöld   +5 more
semanticscholar   +1 more source

Extra force in $f(R)$ modified theories of gravity

, 2007
The equation of motion for test particles in $f(R)$ modified theories of gravity is derived. By considering an explicit coupling between an arbitrary function of the scalar curvature, $R$, and the Lagrangian density of matter, it is shown that an extra ...
Christian G. Böhmer, Francisco S. N. Lobo, Orfeu Bertolami, R. M. Wald, S. Nojiri, Tiberiu Harko, V. Faraoni   +6 more
core   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

The Electromagnetic Unification of Four Forces and Electromagnetic Structures of Particles

OALib, 2018
Recently, the book “Electromagnetic Unification of Four Forces” (ISBN978-3-659-76798-2) was published, compiling the progressions in physics made by the world people, manifested in television while led notably by me and the Members in the world satellite networks from India, Zhejiang and USA.
openaire   +2 more sources

Flexible Piezoelectric Tactile Sensor Array for Dynamic Three-Axis Force Measurement

Italian National Conference on Sensors, 2016
A new flexible piezoelectric tactile sensor array based on polyvinylidene fluoride (PVDF) film is proposed for measuring three-axis dynamic contact force distribution.
Ping Yu, Wei-ting Liu, C. Gu, Xiaoying Cheng, Xin Fu   +4 more
semanticscholar   +1 more source

The relativistic statistical theory and Kaniadakis entropy: an approach through a molecular chaos hypothesis

, 2006
We have investigated the proof of the $H$ theorem within a manifestly covariant approach by considering the relativistic statistical theory developed in [G. Kaniadakis, Phy. Rev. E {\bf 66}, 056125, 2002; {\it ibid.} {\bf 72}, 036108, 2005].
Abe, Abe, Chernikov, Cravero, Ehlers, Hakim, Juttner, Kaniadakis, Kaniadakis, Kaniadakis, Kaniadakis, Kaniadakis, Kaniadakis, Kaniadakis, Lima, Mariz, Marrot, R. Silva, Rajaonarison, Rossani, Scarfone, Silva, Silva, Tauber, Teweldeberhan   +24 more
core   +2 more sources

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Force Myography to Control Robotic Upper Extremity Prostheses: A Feasibility Study

Frontiers in Bioengineering and Biotechnology, 2016
Advancement in assistive technology has led to the commercial availability of multi-dexterous robotic prostheses for the upper extremity. The relatively low performance of the currently used techniques to detect the intention of the user to control such ...
Erina Cho, Richard Chen, Lukas-Karim Merhi, Z. Xiao, Brittany Pousett, C. Menon   +5 more
semanticscholar   +1 more source