Results 151 to 160 of about 4,474,733 (245)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A systems level approach to integrated care: four key functions

International Journal of Integrated Care, 2013
Petra Bywood, Jodie Oliver-Baxter, Lynsey Brown   +2 more
doaj   +3 more sources

Diffractionless transmission of optical beams through a four-level atomic system affected by a plasmonic nanostructure. [PDF]

Sci Rep
Lotfi P, Sahrai M, Siahpoush V, Vafafard A.   +3 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Two-channel optical bistability and multistability in a degenerate four-level atomic medium under a static magnetic field. [PDF]

Sci Rep
Hien NTT, Dan NL, Bang NH, Khoa DX, Van Phu N, Anh NTL, Huong MTT, Nhung LTC, Linh TTT, Thuy LT, Chau NTY, Anh LNM, Van Doai L.   +12 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Interaction of a four-level atom with a quantized field in the presence of a nonlinear Kerr medium. [PDF]

Sci Rep
Almalki S, Berrada K, Abdel-Khalek S, Eleuch H.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Enhancing occupational therapy education: Evaluating the impact of a STEAM-based assistive technology curriculum using Kirkpatrick's four-level model. [PDF]

Br J Occup Ther
Hung CH, Chen MH, Fan SC.
europepmc   +1 more source

Stand-alone polyetheretherketone cages for anterior cervical discectomy and fusion for successive four-level degenerative disc disease without plate fixation. [PDF]

J Craniovertebr Junction Spine, 2020
Ashour AM, Ashour AM, Abdelmohsen I, Sawy ME, Toubar AF.   +4 more
europepmc   +1 more source