Results 51 to 60 of about 17,972,436 (209)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Analysis of the Existence and Stability of Solutions for a Class of Four-Term Fractional Differential Equations

Journal of Mathematics
This study investigates a category of high-order sequential fractional boundary value problems involving four-term fractional derivatives. Motivated by the nonlocal properties of fractional calculus and the limitations of available models with fewer ...
Debao Yan
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Analysis of some localized boundary-domain integral equations for transmission problems with variable coefficients [PDF]

, 2011
This is the post-print version of the Article. The official published version can be found at the links below - Copyright @ 2011 Birkhäuser Boston.Some segregated systems of direct localized boundary-domain integral equations (LBDIEs) associated with ...
Mikhailov, SE, O. Chkadua, S. E. Mikhailov, Natroshvili, D, D. Natroshvili   +4 more
core   +1 more source

Nonlocal Nonlinear Fractional-Order Sequential Hilfer–Caputo Multivalued Boundary-Value Problems

Mathematics
This paper is concerned with the investigation of a nonlocal sequential multistrip boundary-value problem for fractional differential inclusions, involving (k1,ψ1)-Hilfer and (k2,ψ2)-Caputo fractional derivative operators, and (k2,ψ2)- Riemann–Liouville ...
Sotiris K. Ntouyas, Bashir Ahmad, Jessada Tariboon   +2 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Existence, Stability, and Circular Interactions in m-Cyclic Coupled Systems of Sequential (k,ψ)-Hilfer and (k,ψ)-Caputo Type with Boundary Conditions

Fractal and Fractional
This paper examines an m-cyclic coupled system of sequential (k,ψ)-Hilfer and (k,ψ)-Caputo fractional differential equations with boundary conditions. The nonlinearities follow a cyclic pattern: for j=1,…,m−1, fj depends on xj and xj+1 and fm depends on ...
F. Gassem, Mohammed Almalahi, Khaled Aldwoah, Arafa Dawood, Alawia Adam, Amer Alsulami, L. M. Abdalgadir   +6 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source