Results 41 to 50 of about 409,958 (292)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Shape-preserving and unidirectional frequency conversion using four-wave mixing Bragg scattering [PDF]

, 2018
In this work, we investigate the properties of four-wave mixing Bragg scattering in a configuration that employs orthogonally polarized pumps in a birefringent waveguide. This configuration enables a large signal conversion bandwidth, and allows strongly
Bell, Bryn A., Christensen, Jesper B., Koefoed, Jacob G., McKinstrie, Colin J., Rottwitt, Karsten   +4 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Multi-Way Noiseless Signal Amplification in a Symmetrical Cascaded Four-Wave Mixing Process

Photonics, 2022
According to the fundamental laws of quantum optics, vacuum noise is inevitably added to the signal when one tries to amplify a signal. However, it has been recently shown that noiseless signal amplification can be realized when a phase-sensitive process
Hailong Wang, Yajuan Zhang, Xiong Zhang, Chunliu Zhao, Shangzhong Jin, Jietai Jing   +5 more
doaj   +1 more source

Polarization-dependent optical nonlinearities of multiquantum-well laser amplifiers studied by four-wave mixing [PDF]

, 1997
We present a detailed study of the polarization properties of four-wave mixing in multiquantum-well (MQW) semiconductor optical amplifiers (SOA's). In particular, the polarization selection rules relevant to all processes contributing to the generation ...
Hunziker, Guido, Koren, Uzi, Paiella, Roberto, Vahala, Kerry J.   +3 more
core  

Cascaded four-wave mixing in tapered plasmonic nanoantenna

, 2012
We study theoretically the cascaded four-wave mixing (FWM) in broadband tapered plasmonic nanoantennas and demonstrate a 300-fold increase in nonlinear frequency conversion detected in the main lobe of the nanoantenna far-field pattern.
A. E. Miroshnichenko, Abb, Bharadwaj, Danckwerts, Grady, Harutyunyan, Hentschel, Humphrey, I. S. Maksymov, Ko, Lippitz, Maksymov, Maksymov, Maksymov, Maksymov, Maksymov, Maksymov, Minovich, Navarro-Cia, Palomba, Pavlov, Schumacher, Slablab, Stockman, Yu. S. Kivshar   +24 more
core   +1 more source

Efficiency of broadband four-wave mixing wavelength conversion using semiconductor traveling-wave amplifiers [PDF]

, 1994
We present a theoretical analysis and experimental measurements of broadband optical wavelength conversion by four-wave mixing in semiconductor traveling-wave amplifiers.
Dawson, Jay W., Miller, Barry I., Newkirk, Michael A., Park, Namkyoo, Vahala, Kerry J., Zhou, Jianhui   +5 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Solitary Waves in Discrete Media with Four Wave Mixing [PDF]

, 2005
In this paper, we examine in detail the principal branches of solutions that arise in vector discrete models with nonlinear inter-component coupling and four wave mixing.
Horne, R. L., Kevrekidis, P. G., Whitaker, N.   +2 more
core   +3 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source