SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner. [PDF]
PLoS ONE, 2014 The Forkhead transcription factor FOXA2 plays a fundamental role in controlling metabolic homeostasis in the liver during fasting. The precise molecular regulation of FOXA2 in response to nutrients is not fully understood.
Rogier van Gent +6 more
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Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation [PDF]
npj Regenerative MedicineNotochordal cells (NC) have promise as a regenerative therapy for intervertebral disc (IVD) degeneration, but their maintenance in culture remains challenging.
Sajjad Ashraf +7 more
doaj +2 more sources
FOXA2 regulated by HDAC3-mediated deacetylation attenuates neuropathic pain by modulating microglial lipid metabolism and synaptic pruning dysregulation [PDF]
Journal of NeuroinflammationBackground Persistent neuroinflammation and synaptic dysregulation in the spinal dorsal horn (SDH) has been well-established as a critical mechanism contributing to neuropathic pain (NP). Microglia play a pivotal role in modulating both neuroinflammatory
Hui Zeng +11 more
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FOXA2/miR-148a-3p/SMURF2 signaling feed-forward loop alleviates spinal cord ischemia-reperfusion injury-induced neuropathic pain by modulating microglia polarization in rats [PDF]
Frontiers in ImmunologyBackgroundMicroglia polarization is crucial in mediating neuropathic pain. However, the role of microglia polarization in regulating spinal cord ischemia-reperfusion injury (SCIRI)-induced neuropathic pain is largely unknown.
Xiaotong Hao +8 more
doaj +2 more sources
FOXA2 promotes metastatic competence in small cell lung cancer [PDF]
Nature CommunicationsSmall cell lung cancer (SCLC) is known for its high metastatic potential, with most patients demonstrating clinically evident metastases in multiple organs at diagnosis.
Kenta Kawasaki +28 more
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Foxa2 attenuates steatosis and inhibits the NF-κB/IKK signaling pathway in nonalcoholic fatty liver disease [PDF]
PeerJ, 2023 Objective Forkhead box a2 (Foxa2) is proven to be an insulin-sensitive transcriptional regulator and affects hepatic steatosis. This study aims to investigate the mechanism by which Foxa2 affects nonalcoholic fatty liver disease (NAFLD).
Li Yang +5 more
doaj +2 more sources
Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency
Cell Death and Disease, 2021 FOXA2 has been identified as an essential factor for pancreas development and emerging evidence supports an association between FOXA2 and diabetes. Although the role of FOXA2 during pancreatic development is well-studied in animal models, its role during
Ahmed K. Elsayed +4 more
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FoXA2 promotes esophageal squamous cell carcinoma progression by ZEB2 activation
World Journal of Surgical Oncology, 2021 Background It has been reported that Forkhead transcription family member (FOXA2) regulates esophageal squamous cell carcinoma (ESCC) progression. However, the specific mechanism, by which FOXA2 promotes ESCC malignant progression, remains unclear ...
Hanjing Gao +3 more
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Endometrial expression of FOX proteins (FOXA1 and FOXA2) in women of reproductive age with different endometrial thickness: prospective cohort comparative study [PDF]
Гинекология, 2023 Aim. To evaluate the expression of FOX proteins (FOXA1 and FOXA2) in the endometrium during the implantation window in women with a history of reproductive dysfunctions with different thickness of the endometrium. Materials and methods.
Natalia V. Aganezova +4 more
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Cell Death and Disease, 2022 FOXA2 has been known to play important roles in liver functions in rodents. However, its role in human hepatocytes is not fully understood. Recently, we generated FOXA2 mutant induced pluripotent stem cell (FOXA2−/−iPSC) lines and illustrated that loss ...
Maryam Aghadi +2 more
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