Results 111 to 120 of about 19,594 (220)

Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus [PDF]

, 2014
We have previously shown that hepatitis C virus (HCV) infection modulates the expression of forkhead box transcription factors, including FoxO1 and FoxA2, which play key roles in gluconeogenesis and β-oxidation of fatty acid, respectively. The aim of the
Bose, Sandip K, Davidson, Nicholas O, Kim, Hangeun, Meyer, Keith, Ray, Ranjit, Wolins, Nathan   +5 more
core   +2 more sources

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines. [PDF]

, 2016
A challenge facing the human pluripotent stem cell (hPSC) field is the variability observed in differentiation potential of hPSCs. Variability can lead to time consuming and costly optimisation to yield the cell type of interest.
Greenhough, S., Lycke, M., Mathapati, S., Naumovska, E., Siller, R., Sullivan, G.J.   +5 more
core   +1 more source

The emerging role of CAMK1D in diabetes, metabolism and feeding behaviours: A mechanistic systematic review

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
This systematic review synthesizes evidence from published studies, GWAS and grey literature (patents) to show that CAMK1D is implicated in diabetes, obesity, insulin resistance and altered feeding behaviours, with diagnostic potential and mechanistic relevance through regulatory binding and tissue‐specific effects.
Livio Tarchi, Annalisa Di Giacomo, Lorenzo Bonacchi, Andrea Di Santo, Paolo Rovero, Chiara Sassoli, Rachele Garella, Roberta Squecco, Gianluca Villa, Romina Nassini, Francesco De Logu, Tiziana Pisano, Valdo Ricca, Giovanni Castellini   +13 more
wiley   +1 more source

NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression

iScience
Summary: N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation of histone H4 (Nt-Ac-H4), but its role in breast cancer metastasis remains unknown.
Mengying Xing, Bing Yao, Jiaxuan Xu, Peifen Lu, Qixiang Li, Dongliang Wu, Bing Chen, Jiwu Wei, Lei Su, Quan Zhao   +9 more
doaj   +1 more source

miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]

, 2019
open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J., El-Seed, Hesham, Ismail, Amin, Lai, Shanshan, Liu, Dan, Wu, Desheng, Xiao, Jianbo, Zhao, Chao, Zou, Xiaobo   +8 more
core   +1 more source

Dynamic Gelatin Hydrogels Crosslinked by Dithiolane‐Norbornene Click Chemistry

Macromolecular Bioscience, Volume 26, Issue 2, February 2026.
Gelatin‐norbornene (GelNB) and poly(ethylene glycol)‐tetra‐lipoic acid (PEG4LA) are modularly photo‐crosslinked into gelatin‐based hydrogels with dynamically tunable mechanics for expansion and differentiation of induced pluripotent stem cells (iPSC). ABSTRACT Hydrogels prepared from gelatin are ideal for mimicking the extracellular matrix (ECM) owing ...
Favour O. Afolabi, Lydia Yang He, Chien‐Chi Lin   +2 more
wiley   +1 more source

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion [PDF]

, 2017
Glucagon plays a major role in the regulation of glucose homeostasis during fed and fasting states. However, the mechanisms responsible for the regulation of pancreatic α cell mass and function are not completely understood.
Alvin C. Powers, Danielle Dean, Ernesto Bernal-Mizrachi, Finak, George K. Gittes, Göpel, Jennifer Chase, Jennifer Gimeno, Kelsey Cummings, Manuel Blandino-Rosano, Markus A. Rüegg, Michael N. Hall, Mizushima, Nadejda Bozadjieva, Patrick E. MacDonald, Walker, Xiao-Qing Dai, Yang   +17 more
core   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan, Eva Troyano‐Rodriguez, Jennifer Ihuoma, Sharon Negri, Rakesh Rudraboina, Aleksandra Kosmider, Shantipriya Awasthi, Priya Balasubramanian, Shannon Conley, Andriy Yabluchanskiy, Anna Csiszar, Zoltan Ungvari, Rafael de Cabo, Stefano Tarantini   +13 more
wiley   +1 more source

Foxa1 and Foxa2 regulate bile duct development in mice

Journal of Hepatology, 2010
COMMENTARY ON: Foxa1 and Foxa2 regulate bile duct development in mice. J Clin Invest 2009;119:1537–45.Journal of Clinical Investigation. Online by Li Z. et al. Copyright 2009 by American society for Clinical Investigation. Reprinted with permission of American Society for Clinical Investigation in the format Journal via Copyright Clearance Center ...
openaire   +2 more sources