Results 121 to 130 of about 19,594 (220)

Functional Difference of MYC and MYCN in Combined Hepatocellular–Cholangiocarcinoma: Regulation of Differentiation by HNF1B

Cancer Science, Volume 117, Issue 2, Page 536-547, February 2026.
Combined hepatocellular–cholangiocarcinoma (cHCC‐CCA) is a tumor consisting of a mixture of hepatocellular carcinoma and intrahepatic cholangiocarcinoma (CCA) components, but the mechanisms of development are poorly understood. The activation of Myc may be implicated in the formation of cHCC‐CCA and this work demonstrates for the first time that Myc ...
Masanori Goto, Masahiro Yamamoto, Hiroki Tanaka, Yumiko Fujii, Kumi Takasawa, Yuki Kamikokura, Masayo Kamikokura, Nobuyuki Kobayashi, Taro Murakami, Yuji Nishikawa, Akira Takasawa   +10 more
wiley   +1 more source

Generation of an iPSC line from congenital hypopituitarism patient with a nonsense heterozygous variant in FOXA2

Stem Cell Research
Forkhead box A2 (FOXA2) is a pioneer transcription factor, necessary for human development. Mutations in FOXA2 were recently associated with congenital hypopituitarism (CH); however, the pathogenic mechanism remains unknown.
Camilletti Maria Andrea, Chirino Felker Gonzalo Tomás, Castañeda Sheila, Zabalegui Federico, Amin Guadalupe, Belgorosky Alicia, Ciaccio Marta, Di Palma Maria Isabel, Vaiani Elisa, Waisman Ariel, Miriuka Santiago, Pérez Millán María Inés, Moro Lucia Natalia   +12 more
doaj   +1 more source

Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors [PDF]

, 2014
During gastrulation, epiblast cells are pluripotent and their fate is thought to be constrained principally by their position. Cell fate is progressively restricted by localised signalling cues from areas including the primitive streak.
Acampora, Arnold, Arnold, Baldwin, Beddington, Beddington, Beddington, Ben-Haim, Bernemann, Blauwkamp, Brault, Brons, Burtscher, Cajal, Cambray, Candia, Canham, Chambers, Chapman, Clements, Conlon, Davies, Deschamps, Du, Faunes, Forlani, Gadue, Gamer, Gilchrist, Goulding, Greber, Grindley, Guo, Han, Hayashi, Hsieh, Huang, Inman, Iwafuchi-Doi, Kelly, Kim, Kinder, Kinder, Kispert, Kojima, Kubo, Latinkić, Lawson, Lawson, Lee, Lendahl, Liu, Lyashenko, Martin, Martin, Mohamed, Morrisey, Murray, Olivera-Martinez, Osorno, Pfister, Radice, Ring, Rivera-Pérez, Saga, Sasaki, Schubert, Searcy, Sefton, Smyth, Sumi, Takada, Tam, Teo, Tesar, Tzouanacou, Vallier, Wilkinson, Wood, Yamaguchi, Ying   +80 more
core   +2 more sources

Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord

PLOS Genetics, 2015
A main challenge of modern biology is to understand how specific constellations of genes are activated to differentiate cells and give rise to distinct tissues. This study focuses on elucidating how gene expression is initiated in the notochord, an axial structure that provides support and patterning signals to embryos of humans and all other chordates.
José-Edwards, Diana S., Oda-Ishii, Izumi, Kugler, Jamie E., Passamaneck, Yale J., Katikala, Lavanya, Nibu, Yutaka, Di Gregorio, Anna   +6 more
openaire   +4 more sources

Endoderm Generates Endothelial Cells during Liver Development

Stem Cell Reports, 2014
Organogenesis requires expansion of the embryonic vascular plexus that migrates into developing organs through a process called angiogenesis. Mesodermal progenitors are thought to derive endothelial cells (ECs) that contribute to both embryonic ...
Orit Goldman, Songyan Han, Wissam Hamou, Vanina Jodon de Villeroche, Georges Uzan, Heiko Lickert, Valerie Gouon-Evans   +6 more
doaj   +1 more source

Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells [PDF]

, 2017
Type 2–associated goblet cell hyperplasia and mucus hypersecretion are well known features of asthma. 15-Lipoxygenase-1 (15LO1) is induced by the type 2 cytokine IL-13 in human airway epithelial cells (HAECs) in vitro and is increased in fresh asthmatic ...
Aldrovandi, Maceler, Claesson, Hans-Erik, Coleman, John M., Etling, Emily, Kagan, Valerian, Lauder, Sarah, Minami, Yoshinori, O'Donnell, Valerie Bridget, Tyrrell, Victoria, Wenzel, Sally, Zhao, Jingmin   +10 more
core   +2 more sources

LINC00261 and the Adjacent Gene FOXA2 Are Epithelial Markers and Are Suppressed during Lung Cancer Tumorigenesis and Progression

Non-Coding RNA, 2018
Lung cancer continues to be the leading cause of cancer-related deaths worldwide, with little improvement in patient survival rates in the past decade. Long non-coding RNAs (lncRNAs) are gaining importance as possible biomarkers with prognostic potential.
Sonam Dhamija, Andrea C. Becker, Yogita Sharma, Ksenia Myacheva, Jeanette Seiler, Sven Diederichs   +5 more
doaj   +1 more source

The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals

BMC Medical Genetics, 2012
Background Variations within the FOXA family have been studied for a putative contribution to the risk of type 2 diabetes (T2D), and recently the minor T-allele of FOXA2 rs1209523 was reported to associate with decreased fasting plasma glucose levels in ...
Banasik Karina, Hollensted Mette, Andersson Ehm, Sparsø Thomas, Sandbæk Annelli, Lauritzen Torsten, Jørgensen Torben, Witte Daniel R, Pedersen Oluf, Hansen Torben   +9 more
doaj   +1 more source

Circadian Entrainment Triggers Maturation of Human In Vitro Islets

, 2020
Stem-cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human pluripotent stem cells (hPSCs) differentiate into pancreatic islets in vitro by profiling DNA ...
Alvarez-Dominguez, J., Charlton, J., Donaghey, J., Helman, A., Kenty, J., Meissner, A., Melton, D., Rasouli, N., Straubhaar, J.   +8 more
core   +1 more source

The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression

Cell Reports, 2015
Long non-coding RNAs (lncRNAs) regulate diverse biological processes, including cell lineage specification. Here, we report transcriptome profiling of human endoderm and pancreatic cell lineages using purified cell populations.
Wei Jiang, Yuting Liu, Rui Liu, Kun Zhang, Yi Zhang   +4 more
doaj   +1 more source