Results 11 to 20 of about 19,594 (220)
FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation [PDF]
Cell Reports, 2019 Summary: Transcriptional regulatory mechanisms of lineage priming in embryonic development are largely uncharacterized because of the difficulty of isolating transient progenitor populations.
Kihyun Lee +6 more
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Targeted depletion of uterine glandular Foxa2 induces embryonic diapause in mice
eLife, 2022 Embryonic diapause is a reproductive strategy in which embryo development and growth is temporarily arrested within the uterus to ensure the survival of neonates and mothers during unfavorable conditions.
Mitsunori Matsuo +6 more
doaj +3 more sources
Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells
Molecular Metabolism, 2017 Objective: The transcription factors (TF) Foxa2 and Pdx1 are key regulators of beta-cell (β-cell) development and function. Mutations of these TFs or their respective cis-regulatory consensus binding sites have been linked to maturity diabetes of the ...
Aimée Bastidas-Ponce +6 more
doaj +4 more sources
Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation. [PDF]
PLoS ONE, 2012 The forkhead box protein A2 (FOXA2) is an important regulator of glucose and lipid metabolism and organismal energy balance. Little is known about how FOXA2 protein expression and activity are regulated by post-translational modifications.
Narasimhaswamy S Belaguli +3 more
doaj +1 more source
Foxa2 regulates multiple pathways of insulin secretion [PDF]
Journal of Clinical Investigation, 2004 The regulation of insulin secretion by pancreatic beta cells is perturbed in several diseases, including adult-onset (type 2) diabetes and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). The first mouse model for PHHI has a conditional deletion of the gene encoding the winged-helix transcription factor Foxa2 (Forkhead box a2, formerly ...
Kristen A, Lantz +5 more
openaire +2 more sources
Uncovering the role of FOXA2 in the Development of Human Serotonin Neurons
Advanced Science, 2023 Directed differentiation of serotonin neurons (SNs) from human pluripotent stem cells (hPSCs) provides a valuable tool for uncovering the mechanism of human SN development and the associated neuropsychiatric disorders.
Ting Xu +10 more
doaj +1 more source
Foxa2 regulates alveolarization and goblet cell hyperplasia [PDF]
Development, 2004 The airways are lined by several distinct epithelial cells that play unique roles in pulmonary homeostasis; however, the mechanisms controlling their differentiation in health and disease are poorly understood. The winged helix transcription factor, FOXA2, is expressed in the foregut endoderm and in subsets of respiratory epithelial cells in the fetal ...
Huajing, Wan +8 more
openaire +2 more sources
Nuclear Export-independent Inhibition of Foxa2 by Insulin [PDF]
Journal of Biological Chemistry, 2009 The Forkhead box A2 transcription factor (Foxa2/HNF-3beta) has been shown to be a key regulator of genes involved in the maintenance of glucose and lipid homeostasis in the liver. It is constitutively inactivated in several hyperinsulinemic/obese mouse models, thereby enhancing their metabolic phenotypes. Foxa2 is activated under fasting conditions but
Jessica J, Howell, Markus, Stoffel
openaire +2 more sources
Advanced Science, 2023 The forkhead box transcription factor A2 (FOXA2) is a transcription factor and plays a key role in embryonic development, metabolism homeostasis and tumor cell proliferation; however, its regulatory potential in CRC is not fully understood.
Xin Liu +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Foxa2, a member of the Forkhead box (Fox) family of transcription factors, plays an important role in the regulation of lung function and lung tissue homeostasis. FOXA2 expression is reduced in the lung and airways epithelium of asthmatic patients and in
Diana C. Yánez +9 more
doaj +1 more source