Results 191 to 200 of about 19,594 (220)

Confined target search powers FOXA2 transcription activity

2022
SMT trajectory data for "Confined target search powers FOXA2 transcription activity" Zuhui Wang1,2†, Di Niu1,2,3†, Claudia Cattoglio4,5, Ying Bi1,2, Luke D Lavis6, Kyle M Loh7, Wulan Deng1,2,3, * 1Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing 100871, China.
Wang, Zuhui, Niu, Di, Cattoglio, Claudia, Bi, Ying, Lavis, Luke D, Loh, Kyle M, Deng, Wulan   +6 more
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Regulation of adaptive behaviour during fasting by hypothalamic Foxa2

Nature, 2009
The lateral hypothalamic area is considered the classic 'feeding centre', regulating food intake, arousal and motivated behaviour through the actions of orexin and melanin-concentrating hormone (MCH). These neuropeptides are inhibited in response to feeding-related signals and are released during fasting. However, the molecular mechanisms that regulate
Jose P, Silva, Ferdinand, von Meyenn, Jessica, Howell, Bernard, Thorens, Christian, Wolfrum, Markus, Stoffel   +5 more
openaire   +2 more sources

Foxa2 may modulate hepatic apoptosis through the cIAP1 pathway

Cellular Signalling, 2013
Hepatocyte apoptosis is a ubiquitous feature of chronic liver injury, but the molecular mechanism remains to be determined. The liver-enriched Foxa2 transcription factor has been implicated in inflammation and neoplasia. Foxa2 may play a role in the regulation of apoptosis.
Kewei, Wang, John J, Brems, Richard L, Gamelli, Ai-Xuan, Holterman   +3 more
openaire   +2 more sources

β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation

Oncogene, 2012
The Wnt/β-catenin signaling is essential for various organogenesis and is often implicated during tumorigenesis. Dysregulated β-catenin signaling is associated with the formation of endometrial adenocarcinomas (EACs), which is considered as the common form of endometrial cancer in women. In the current study, we investigate the downstream target of Wnt/
M, Villacorte, K, Suzuki, A, Hirasawa, Y, Ohkawa, M, Suyama, T, Maruyama, D, Aoki, Y, Ogino, S, Miyagawa, T, Terabayashi, Y, Tomooka, N, Nakagata, G, Yamada   +12 more
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FOXA2 Promotes Prostate Cancer Lineage Plasticity through KIT

Cancer Discovery, 2022
Abstract FOXA2 drives the adeno-to-neuroendocrine lineage transition in prostate cancer through KIT activation.
openaire   +1 more source

GATA6 and FOXA2 RegulateWnt6Expression During Extraembryonic Endoderm Formation

Stem Cells and Development, 2012
One of the earliest epithelial-to-mesenchymal transitions in mouse embryogenesis involves the differentiation of inner cell mass cells into primitive and then into parietal endoderm. These processes can be recapitulated in vitro using F9 teratocarcinoma cells, which differentiate into primitive endoderm when treated with retinoic acid (RA) and into ...
Jason T K, Hwang, Gregory M, Kelly
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Foxa2, a novel transcriptional regulator of insulin sensitivity

Nature Medicine, 2006
The transcriptional network downstream of the insulin receptor is incompletely understood, but recent data identify a new player. Foxa2—a forkhead transcription factor—controls hepatic lipid metabolism in fasting and type 2 diabetes, improving insulin resistance in peripheral tissues.
Pere Puigserver, Joseph T Rodgers
openaire   +1 more source

[Down-expression of FOXA2 in gastric adenocarcinoma].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2015
To investigate the expression of FOXA2 in human gastric adenocarcinoma and its correlation with cell migration and invasion.Fifty-six pairs of gastric adenocarcinoma and matched tumor-adjacent tissues were freshly collected. The expressions of FOXA2 and epithelial cadherin (E-cadherin) in the gastric specimens were detected using immunohistochemistry ...
Zhengliang, Zhang, Jiangli, Sun, Zhenghai, Bai, Haijun, Li, Shicai, He, Rui, Chen, Xiangming, Che   +6 more
openaire   +1 more source

Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010
The expression of Sox14 gene in spinal cord explants was found to be regulated by Sonic hedgehog (SHH) in a dose-dependent manner, indicating that this signaling molecule might act as a regulator of Sox14-expressing interneuron differentiation. In the present study we identified the positive control element and provided the first evidence that FOXA2 is
Popović, Jelena, Lazić, Andrijana, Petrović, Isidora, Stevanović, Milena   +3 more
openaire   +3 more sources

FOXA2–KIT-driven lineage plasticity in NEPC

Nature Reviews Urology, 2022
openaire   +2 more sources