Results 31 to 40 of about 19,594 (220)

FOXA2 PROMOTES PROSTATE CANCER BONE COLONIZATION

The FASEB Journal, 2018
Background It is estimated that 26,000 men will die from prostate cancer (PCa) in 2017. Androgen deprivation therapy (ADT) is the gold standard treatment for advanced PCa. Initially, patients respond to treatment, however, these tumors almost invariably progress to castrate‐resistant PCa, for which there is no ...
zachary m. connelly, Shu Yang, A. Wayne Orr, Xiuping Yu   +3 more
openaire   +1 more source

Forkhead box protein A2 alleviates toll-like receptor 4-mediated inflammation, endoplasmic reticulum stress, autophagy, and apoptosis induced by lipopolysaccharide in bovine hepatocytes

Journal of Dairy Science, 2023
: Lipopolysaccharide (LPS) is an important stimulus of inflammation via binding to toll-like receptor 4 (TLR4), but the role of TLR4 in LPS-induced cellular homeostasis disruption indicated by the increased level of endoplasmic reticulum (ER) stress ...
Wan Xie, Yang Xue, Xiaokun Song, Hongzhu Zhang, Guangjun Chang, Xiangzhen Shen   +5 more
doaj   +1 more source

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3. [PDF]

, 2017
Mesoderm derived from human embryonic stem cells (hESCs) is a major source of the mesenchymal stem/stromal cells (MSCs) that can differentiate into osteoblasts and chondrocytes for tissue regeneration.
Aghaloo, Tara, Deng, Peng, Hong, Christine, Szymanski, John M, Wang, Cun-Yu, Yu, Bo, Yu, Yongxin   +6 more
core   +2 more sources

MicroRNA-1246 Promotes Melanoma Progression Through Targeting FOXA2.

OncoTargets and therapy, 2020
Recently, the incidence of melanoma has been rising and there is a lack of effective targeted therapies. The regulatory mechanisms of microRNA-1246 (miR-1246) have been found in many cancers, except melanoma. This study focused on the regulatory mechanism of miR-1246 in melanoma development.The expression of miR-1246 was assessed using quantitative ...
Yu,Yanhua, Yu,Fang, Sun,Pijiang
openaire   +3 more sources

Foxa2 Regulates Leukotrienes to Inhibit Th2-mediated Pulmonary Inflammation [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2013
Foxa2 is a member of the Forkhead family of nuclear transcription factors that is highly expressed in respiratory epithelial cells of the developing and mature lung. Foxa2 is required for normal airway epithelial differentiation, and its deletion causes goblet-cell metaplasia and Th2-mediated pulmonary inflammation during postnatal development.
Xiaoju, Tang, Xiaojing J, Liu, Cuijie, Tian, Qiaoli, Su, Yi, Lei, Qingbo, Wu, Yangyan, He, Jeffrey A, Whitsett, Fengming, Luo   +8 more
openaire   +2 more sources

Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain [PDF]

, 2014
The development of the nervous system is critically dependent on the production of functionally diverse neuronal cell types at their correct locations.
Carcagno, Abel Luis, Di Bella, Daniela Jesica, Goulding, Martyn, Guillemot, Francois, Lanuza, Guillermo Marcos   +4 more
core   +1 more source

Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism [PDF]

Cell Metabolism, 2013
Circulating levels of insulin and glucagon reflect the nutritional state of animals and elicit regulatory responses in the liver that maintain glucose and lipid homeostasis. The transcription factor Foxa2 activates lipid metabolism and ketogenesis during fasting and is inhibited via insulin-PI3K-Akt signaling-mediated phosphorylation at Thr156 and ...
von Meyenn, Ferdinand, Porstmann, Thomas, Gasser, Emanuel, Selevsek, Nathalie, Schmidt, Alexander, Aebersold, Ruedi, Stoffel, Markus   +6 more
openaire   +3 more sources

FOXA2 suppresses endometrial carcinogenesis and epithelial-mesenchymal transition by regulating enhancer activity

The Journal of Clinical Investigation, 2022
FOXA2 encodes a transcription factor mutated in 10% of endometrial cancers (ECs), with a higher mutation rate in aggressive variants. FOXA2 has essential roles in embryonic and uterine development.
Subhransu S. Sahoo, Susmita G. Ramanand, Yunpeng Gao, Ahmed Abbas, Ashwani Kumar, Ileana C. Cuevas, Hao-Dong Li, Mitzi Aguilar, Chao Xing, Ram S. Mani, Diego H. Castrillon   +10 more
doaj   +1 more source

Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells [PDF]

, 2012
Peer reviewedPublisher ...
A Kubo, AK Teo, C. H.-H. Cho, D Zhang, E Kroon, E Wandzioch, F. M. Docherty, H Li, H. M. Docherty, IG Brons, J Ameri, J Cai, J Jonsson, JA Thomson, JF Habener, JK Mfopou, JM Wells, JR Spence, K Takahashi, K. Docherty, KA D’Amour, KA Harrison, KS Zaret, L Vallier, L Vallier, L. Vallier, M Inamura, M Polak, M. Joåo Lima, M. W. B. Trotter, MC Nostro, MF Offield, N. R.-F. Hannan, OG Kelly, R Bort, R Maehr, RI Sherwood, S Brown, ST Rashid, T Touboul, V Ramos-Mejia, W Jiang, Y Kunisada   +42 more
core   +2 more sources

Foxa2: The Rise and Fall of Dopamine Neurons [PDF]

Cell Stem Cell, 2008
Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa2(+/-) mice spontaneously develop ...
openaire   +2 more sources