Results 41 to 50 of about 19,594 (220)

CD44 Promotes Breast Cancer Metastasis through AKT-Mediated Downregulation of Nuclear FOXA2

Biomedicines, 2022
The primary cause of breast cancer mortality is the metastatic invasion of cancerous stem cells (CSC). Cluster of differentiation 44 (CD44) is a well-known CSC marker in various cancers, as well as a key role player in metastasis and relapse of breast ...
Anupama Vadhan, Ming-Feng Hou, Priya Vijayaraghavan, Yi-Chia Wu, Stephen Chu-Sung Hu, Yun-Ming Wang, Tian-Lu Cheng, Yen-Yun Wang, Shyng-Shiou F. Yuan   +8 more
doaj   +1 more source

Vagal Blocking for Obesity Control : a Possible Mechanism-Of-Action [PDF]

, 2016
14 September 2016 Erratum to: Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P Skibicka, Perry Barrett, Suzanne Dickson, Jens Holst, Jens Rehfeld, Geoffrey van ...
Adan, Roger, Barrett, Perry, Ben-Menachem, Elinor, Cassie, Nikki, Chen, Duan, Dickson, Suzanne, Holst, Jens, Johannessen, Helene, Kodama, Yosuke, Kulseng, Bård, Rehfeld, Jens, Revesz, David, Skibicka, Karolina P, van der Plasse, Geoffrey, Zhao, Chun-Mei   +14 more
core   +1 more source

Inhibition of mesodermal fate by Xenopus HNF3β/FoxA2

Developmental Biology, 2004
The winged-helix transcription factor HNF3beta/FoxA2 is expressed in embryonic organizing centers of the gastrulating mouse, frog, fish, and chick. In the mouse, HNF3beta is required for the formation of the mammalian node and notochord, and can induce ectopic floor plate formation when misexpressed in the developing neural tube; HNF3beta expression in
Suri, Crystal, Haremaki, Tomomi, Weinstein, Daniel C   +2 more
openaire   +2 more sources

Neurogenin3 Cooperates with Foxa2 to Autoactivate Its Own Expression [PDF]

Journal of Biological Chemistry, 2013
The transcription factor Neurogenin3 functions as a master regulator of endocrine pancreas formation, and its deficiency leads to the development of diabetes in humans and mice. In the embryonic pancreas, Neurogenin3 is transiently expressed at high levels for a narrow time window to initiate endocrine differentiation in scattered progenitor cells. The
Miriam, Ejarque, Sara, Cervantes, Gemma, Pujadas, Anna, Tutusaus, Lidia, Sanchez, Rosa, Gasa   +5 more
openaire   +2 more sources

The Use of Foxa2-Overexpressing Adipose Tissue-Derived Stem Cells in a Scaffold System Attenuates Acute Liver Injury

Gut and Liver, 2019
Background/AimsFor the clinical application of stem cell therapy, functional enhancement is needed to increase the survival rate and the engraftment rate.
Yeon Ji Chae, Dae Won Jun, Jai Sun Lee, Waqar Khalid Saeed, Hyeon Tae Kang, Kiseok Jang, Jin Ho Lee   +6 more
doaj   +1 more source

Foxa1 and Foxa2 regulate bile duct development in mice [PDF]

Journal of Clinical Investigation, 2009
The forkhead box proteins A1 and A2 (Foxa1 and Foxa2) are transcription factors with critical roles in establishing the developmental competence of the foregut endoderm and in initiating liver specification. Using conditional gene ablation during a later phase of liver development, we show here that deletion of both Foxa1 and Foxa2 (Foxa1/2) in the ...
Zhaoyu, Li, Peter, White, Geetu, Tuteja, Nir, Rubins, Sara, Sackett, Klaus H, Kaestner   +5 more
openaire   +2 more sources

Characteristics of expression of proteomic markers in women with “thin” endometrium and their importance for the therapeutic effects of the use of exogenous estradiol: A prospective cohort comparative study [PDF]

Гинекология
Aim. To analyze the relationship between the expression of proteomic markers [estrogen (ER) and progesterone (PR) receptors, LIF, FOXA1, FOXA2] of endometrial receptivity and indicators of the levels of sex steroids [estradiol (E2) and progesterone (P ...
Natalia V. Aganezova, Sergey S. Aganezov, Ksenia E. Gogichashvili   +2 more
doaj   +1 more source

FOXA2 controls the anti-oxidant response in FH-deficient cells

Cell Reports, 2023
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a cancer syndrome caused by inactivating germline mutations in fumarate hydratase (FH) and subsequent accumulation of fumarate. Fumarate accumulation leads to profound epigenetic changes and the activation of an anti-oxidant response via nuclear translocation of the transcription factor NRF2 ...
Rogerson, Connor, Sciacovelli, Marco, Maddalena, Lucas A., Pouikli, Andromachi, Segarra-Mondejar, Marc, Valcarcel-Jimenez, Lorea, Schmidt, Christina, Yang, Ming, Ivanova, Elena, Kent, Joshua, Mora, Ariane, Cheeseman, Danya, Carroll, Jason S., Kelsey, Gavin, Frezza, Christian   +14 more
openaire   +3 more sources

Key transcriptional effectors of the pancreatic acinar phenotype and oncogenic transformation.

PLoS ONE, 2023
Proper maintenance of mature cellular phenotypes is essential for stable physiology, suppression of disease states, and resistance to oncogenic transformation. We describe the transcriptional regulatory roles of four key DNA-binding transcription factors
Ana Azevedo-Pouly, Michael A Hale, Galvin H Swift, Chinh Q Hoang, Tye G Deering, Jumin Xue, Thomas M Wilkie, L Charles Murtaugh, Raymond J MacDonald   +8 more
doaj   +1 more source

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. [PDF]

, 2017
The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic ...
Blazquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guihard, Pierre J, Jumabay, Medet, Spencer, Melissa J, Tontonoz, Peter, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng   +9 more
core   +2 more sources