Results 361 to 370 of about 199,492 (387)
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FOXP3: Of Mice and Men

Annual Review of Immunology, 2006
The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: (a) elimination of self-reactive cells in the thymus during selection and (b) generation of a variety of peripheral regulatory cells to control self ...
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What turns on Foxp3?

Nature Immunology, 2008
Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression.
Harald von Boehmer, Jens Nolting
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Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects

Nutrition, 2016
The aim of this study was to identify regulatory T cell (Treg) subsets residing in adipose tissue, demonstrate their immunosuppressive functions, and assess the possible role of Sirt1 in their function in overweight subjects.Fat samples were obtained by lipoaspiration from healthy overweight (n = 15) and normoweight (n = 11) subjects.
Juan D. Cortés-García   +9 more
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Suppression by human FOXP3 + regulatory T cells requires FOXP3-TIP60 interactions

Science Immunology, 2017
Targeting the FOXP3-TIP60 interaction may modulate T reg activity in IPEX and other autoimmune and inflammatory diseases.
Khalid Bin Dhuban   +16 more
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MLL4 keeps Foxp3 in the loop

Nature Immunology, 2017
The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells.
Hai-Hui Xue, Dong-Mei Zhao
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FOXP3 gene polymorphisms in preeclampsia

American Journal of Obstetrics and Gynecology, 2012
To determine whether polymorphisms in the FOXP3 gene are associated with preeclampsia.Case-control study in which 120 women with preeclampsia were compared with 120 healthy normotensive controls. Genetic variants (single nucleotide polymorphisms and microsatellites) in the FOXP3 gene were analyzed.
Gregory J. Stoddard   +3 more
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FOXP3 ensembles in T‐cell regulation

Immunological Reviews, 2006
Summary:  Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T‐cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding
Kathryn T. Iacono   +8 more
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Insights into transcriptional regulation by FOXP3

Frontiers in Bioscience, 2006
FoxP3 recently entered the spotlight as a critical component of regulatory T cell development and function. Several groups are presently engaged in an effort to uncover the mechanistic details of its contribution to this critical T cell subset. Despite this, the mechanism of FoxP3-mediated transcriptional repression and the affected target genes are ...
Jared E. Lopes   +3 more
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ChIP-on-Chip for FoxP3

2011
Regulatory T (Treg) cells play a key role in dominant suppression of immune response and maintenance of immune homeostasis. Foxp3, a member of the forkhead transcription factor family, is indispensable for Treg cell development and function. Mice and human with Foxp3 mutations are severely impaired in Treg cell generation and develop lethal autoimmune ...
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Persistent Enteropathy in a Toddler with a Novel FOXP3 Mutation and Normal FOXP3 Protein Expression

The Journal of Pediatrics, 2017
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by mutations in the FOXP3 gene. Patients usually present with a clinical triad of intractable diarrhea, diabetes, and eczema. In this patient, FOXP3 protein expression was normal, but FOXP3 Sanger sequencing confirmed the clinical suspicion of IPEX by detecting a ...
Sara Seghezzo   +2 more
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