Results 121 to 130 of about 1,040,831 (304)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Mass independent isotopic fractionation: A key to plasma chemistry
, 2022 François Robert, Peter Reinhardt
openalex +3 more sources
Salt fractionation of plasma proteins: A procedure to teach principles of protein chemistry [PDF]
, 2003 Augusto César Cropanese Spadaro +3 more
openalex +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Filtered density functions from direct numerical simulation of a reactive jet in cross-flow
, 2010 Direct numerical simulation (DNS) with multi-step hydrogen-air chemical kinetics is used to investigate the nearfield of a flame stabilized above a reactive jet in cross-flow (JICF). JICF configurations are typically used where rapid mixing is desirable;
Chen, J.H. +4 more
core
, 2018 A combination of the temporally and spatially resolved phonon spectroscopy has enabled calibration of hydrogen bond transition from the vibration mode of heavy water to the core/shelled nanodroplet and the subnanosized ionic hydration shell in terms of ...
Sun, Chang Q
core +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Tabulated Chemistry Models for Numerical Simulation of Combustion Flow Field
FluidsIn numerical simulations of combustion flow fields, tabulated chemistry models are widely used to reduce computational cost compared to rigorous reaction calculation methods such as detailed chemical reaction calculations.
Masaya Muto
doaj +1 more source