Results 101 to 110 of about 3,164,995 (317)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Relationship Between the Nonlinear Oscillator and the Motor Cortex

IEEE Access, 2019
The investigations show that the fractional calculus could be employed for complex biological systems and capture intrinsic phenomena. At the same time, the research results also show that the neural network has the characteristics of fractional calculus
Qiang Lu
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

FPGA implementation of adaptive sliding mode control and genetically optimized PID control for fractional-order induction motor system with uncertain load

Advances in Difference Equations, 2017
In this paper, we investigate the control of 4-D nonautonomous fractional-order uncertain model of a PI speed-regulated current-driven induction motor (FOIM) using a fractional-order adaptive sliding mode controller (FOASMC).
Karthikeyan Rajagopal, Guessas Laarem, Anitha Karthikeyan, Ashokkumar Srinivasan   +3 more
doaj   +1 more source

Fractional-Order Model Predictive Frequency Control of an Islanded Microgrid

Energies, 2018
Optimal frequency control of an islanded microgrid has been a challenging issue in the research field of microgrids. Recently, fractional-order calculus theory and some related control methods have attempted to handle this issue.
Min-Rong Chen, Guo-qiang Zeng, Yu-Xing Dai, Kang-Di Lu, Da-Qiang Bi   +4 more
semanticscholar   +1 more source

Fractional Model Reference Adaptive PIλDμ Control

Journal of New Results in Science, 2016
This study explains the auto-adjustable fractional order the proportional–integral–derivative (PID) controller design methodology by using the technique of fractional model reference adaptive control (fractional MRAC).
Hüseyin Arpacı, Ömerül Faruk Özgüven, Mehmet Serhat Can   +2 more
doaj  

A Fractional-Order Model for HIV Dynamics in a Two-Sex Population

International Journal of Mathematics and Mathematical Sciences, 2018
Human Immunodeficiency Virus (HIV) is a virus that attacks or infects cells in the immune system that causes immune decline. Acquired Immunodeficiency Syndrome (AIDS) is the most severe stage of HIV infection.
Fatmawati, Endrik Mifta Shaiful, M. I. Utoyo   +2 more
semanticscholar   +1 more source

Diffusion process modeling by using fractional-order models

Applied Mathematics and Computation, 2015
AbstractThis paper deals with a concept and description of a RC network as an electro-analog model of diffusion process which enables to simulate heat dissipation under different initial and boundary conditions. It is based on well-known analogy between heat and electrical conduction.
Dominik Sierociuk, Tomas Skovranek, Michal Macias, Igor Podlubny, Ivo Petrás, Andrzej Dzielinski, Pawel Ziubinski   +6 more
openaire   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source