Results 21 to 30 of about 526,298 (136)

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

Spheres, tears, and spears: Regulating the perimeter and circularity of millimeter‐sized alginate hydrogel beads

AIChE Journal, EarlyView.
Abstract Generating hydrogel beads pertains to many engineering applications. We examined two alginate‐based fluids at three concentrations of alginate, cAG$$ {c}_{\mathrm{AG}} $$. We used the “Map of Misery” to determine which material property (viscosity, elasticity, and inertia) drives droplet formation.
Conor G. Harris, Katherine D. Bandettini, Hannah K. Gedde, Lewis Semprini, Kaitlin C. Fogg, Willie E. Rochefort   +5 more
wiley   +1 more source

Fractional topological insulators in three dimensions

, 2010
Topological insulators can be generally defined by a topological field theory with an axion angle theta of 0 or pi. In this work, we introduce the concept of fractional topological insulator defined by a fractional axion angle and show that it can be ...
Karch, Andreas, Maciejko, Joseph, Qi, Xiao-Liang, Zhang, Shou-Cheng   +3 more
core   +1 more source

Upsampling DINOv2 Features for Unsupervised Vision Tasks and Weakly Supervised Materials Segmentation

Advanced Intelligent Systems, EarlyView.
Feature from recent image foundation models (DINOv2) are useful for vision tasks (segmentation, object localization) with little or no human input. Once upsampled, they can be used for weakly supervised micrograph segmentation, achieving strong results when compared to classical features (blurs, edge detection) across a range of material systems.
Ronan Docherty, Antonis Vamvakeros, Samuel J. Cooper   +2 more
wiley   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Extending Bauer's corollary to fractional derivatives

, 2003
We comment on the method of Dreisigmeyer and Young [D. W. Dreisigmeyer and P. M. Young, J. Phys. A \textbf{36}, 8297, (2003)] to model nonconservative systems with fractional derivatives.
Arthurs A M, Bauer P S, David W Dreisigmeyer, Dreisigmeyer D W, Peter M Young, Riewe F, Riewe F, Tonti E   +7 more
core   +1 more source

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source

Local Polynomial Regression and Filtering for a Versatile Mesh‐Free PDE Solver

International Journal for Numerical Methods in Fluids, EarlyView.
A high‐order, mesh‐free finite difference method for solving differential equations is presented. Both derivative approximation and scheme stabilisation is carried out by parametric or non‐parametric local polynomial regression, making the resulting numerical method accurate, simple and versatile. Numerous numerical benchmark tests are investigated for
Alberto M. Gambaruto
wiley   +1 more source

Nonlinear Resonance Modulation in Single‐Crystalline VO2‐Integrated Si Ring Resonator

Laser &Photonics Reviews, EarlyView.
This work first demonstrates a single‐crystalline VO2–Si hybrid ring resonator. The epitaxial lift‐off process enables high‐quality VO2 integration on the dissimilar Si photonic platform. The high‐quality VO2 film exhibits exceptional nonlinear resonance modulation and a steep optical transition across the metal‐insulator transition. ABSTRACT The metal‐
Sebae Park, Dong Kyu Lee, Junyeop Kim, Sungwon Lee, Heedeuk Shin, Junwoo Son   +5 more
wiley   +1 more source

Existence, Non‐Existence, and Uniqueness of Solutions for a Generalized Fractional p‐Kirchhoff Equation

Mathematische Nachrichten, EarlyView.
ABSTRACT This paper investigates the existence and non‐existence and uniqueness of global solutions for certain parameter values c$c$ in a new class of generalized fractional p$p$‐Kirchhoff equations in the whole space. Using the Pohozaev and Nehari identities for an auxiliary problem, together with the fractional Gagliardo–Nirenberg inequality and the
J. Vanterler da C. Sousa, Romulo Diaz Carlos, El‐Houari Hamza   +2 more
wiley   +1 more source