Results 141 to 150 of about 158,118 (343)

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Analysis on nonlinear differential equation with a deviating argument via Faedo–Galerkin method

Results in Applied Mathematics
This article focuses on the impulsive fractional differential equation (FDE) of Sobolev type with a nonlocal condition. Existence and uniqueness of the approximations are determined via analytic semigroup and fixed point method.
M. Manjula, E. Thilakraj, P. Sawangtong, K. Kaliraj   +3 more
doaj  

ON SOME THEOREMS IN FRACTIONAL CALCULUS FOR SINGULAR FUNCTIONS [PDF]

, 1996
 Fu
openalex   +1 more source

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

Molecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, Sebastià Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto   +14 more
wiley   +1 more source

On Multiplicative Fractional Calculus [PDF]

J. Semigroup Theory Appl. 2016, 2016:2, Available online at http://scik.org, 2015
We set the main concepts for multiplicative fractional calculus. We define Caputo, Riemann and Letnikov multiplicative fractional derivatives and multiplicative fractional integrals and study some of their properties. Finally, the multiplicative analogue of the local conformable fractional derivative and integral is studied.
arxiv  

Mathematical study of the dynamics of lymphatic filariasis infection via fractional-calculus. [PDF]

Eur Phys J Plus, 2023
Alshehri A, Shah Z, Jan R.
europepmc   +1 more source

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

Molecular Oncology, Volume 19, Issue 4, Page 1054-1074, April 2025.
The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits, Barbara Andrea Reinoehl, Renate Wagner, Peter Kuess, Franziska Eckert, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser   +7 more
wiley   +1 more source

Numerical Approximations and Fractional Calculus: Extending Boole’s Rule with Riemann–LiouvilleFractional Integral Inequalities

Fractal and Fractional
This paper develops integral inequalities for first-order differentiable convex functions within the framework of fractional calculus, extending Boole-type inequalities to this domain. An integral equality involving Riemann–Liouville fractional integrals
Abdul Mateen, Wali Haider, Asia Shehzadi, Hüseyin Budak, Bandar Bin-Mohsin   +4 more
doaj   +1 more source

Fractional Partial Differential Equation: Fractional Total Variation and Fractional Steepest Descent Approach-Based Multiscale Denoising Model for Texture Image

Abstract and Applied Analysis, 2013
The traditional integer-order partial differential equation-based image denoising approaches often blur the edge and complex texture detail; thus, their denoising effects for texture image are not very good.
Yi-Fei Pu, Ji-Liu Zhou, Patrick Siarry, Ni Zhang, Yi-Guang Liu   +4 more
doaj   +1 more source

Applications of local fractional calculus to engineering in fractal time-space: Local fractional differential equations with local fractional derivative [PDF]

arXiv, 2011
This paper presents a better approach to model an engineering problem in fractal-time space based on local fractional calculus. Some examples are given to elucidate to establish governing equations with local fractional derivative.
arxiv