Results 51 to 60 of about 11,868 (264)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Planar graphs are 9/2-colorable [PDF]

, 2016
We show that every planar graph $G$ has a 2-fold 9-coloring. In particular, this implies that $G$ has fractional chromatic number at most $\frac92$.
Cranston, Daniel W., Rabern, Landon
core  

H\"older-type inequalities and their applications to concentration and correlation bounds [PDF]

, 2015
Let $Y_v, v\in V,$ be $[0,1]$-valued random variables having a dependency graph $G=(V,E)$. We show that \[ \mathbb{E}\left[\prod_{v\in V} Y_{v} \right] \leq \prod_{v\in V} \left\{ \mathbb{E}\left[Y_v^{\frac{\chi_b}{b}}\right] \right\}^{\frac{b}{\chi_b}},
Pelekis, Christos, Ramon, Jan, Wang, Yuyi   +2 more
core   +5 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Topological methods in zero-sum Ramsey theory

Forum of Mathematics, Sigma
A landmark result of Erdős, Ginzburg, and Ziv (EGZ) states that any sequence of $2n-1$ elements in ${\mathbb {Z}}/n$ contains a zero-sum subsequence of length n.
Florian Frick, Jacob Lehmann Duke, Meenakshi McNamara, Hannah Park-Kaufmann, Steven Raanes, Steven Simon, Darrion Thornburgh, Zoe Wellner   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Optimization of Color Fractionation of Monascus Pigment

Journal of Chemical Engineering and Industrial Biotechnology, 2023
Monascus fungi are unique among the various microorganisms that produce edible pigments, which consist of red, orange and yellow. These pigments are typically present in a mixture. Hence, pigment separation is needed. This study aims to optimize solvent systems that can effectively fractionate the pigments. The optimization was carried out using column
Farhan Mohd Said, Nur Fathin Shamirah Daud   +1 more
openaire   +1 more source