Results 91 to 100 of about 36,584 (264)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

On a differential equation with Caputo-Fabrizio fractional derivative of order 1< β ≤ 2 and application to mass-spring-damper system

, 2016
In this work, we investigate a linear differential equation involving Caputo-Fabrizio fractional derivative of order 1 < b ≤ 2. Under some assumptions the considered equation is reduced to an integer order differential equation and solutions for ...
Sadarangani, Kishin, Al-Salti, Nasser, Karimov, Erkinjon   +2 more
core   +1 more source

Mittag-Leffler Functions and the Truncated V-fractional Derivative

, 2020
In this paper, we introduce a new type of fractional derivative, which we called truncated V-fractional derivative, for α-differentiable functions, by means of the six-parameter truncated Mittag–Leffler function. One remarkable characteristic of this new
Capelas de Oliveira, E., Sousa, J. Vanterler da C.   +1 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Dynamics of the Caputo fractional derivative

In this article we analyse the dynamical behaviour of the Caputo complex fractional derivative. We prove that the Caputo complex fractional derivative operator is Devaney chaotic in the Mittag-Leffler Caputo space.
Murillo-Arcila, Marina, Vargas Moreno, Álvaro, Vargas-Moreno, Álvaro, Murillo Arcila, Marina, Peris Manguillot, Alfredo, Peris, A.   +5 more
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Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Fractional Langevin equation and Riemann-Liouville fractional derivative

, 2007
In this present work we consider a fractional Langevin equation with Riemann-Liouville fractional time derivative which modifies the classical Newtonian force, nonlocal dissipative force, and long-time correlation.
Kwok Sau Fa
core   +1 more source

Fractional Derivatives, Splines And Tomography

, 2000
Publication in the conference proceedings of EUSIPCO, Tampere, Finland ...
Michael Unser, Stefan Horbelt, Thierry Blu   +2 more
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

A New Truncated M-Fractional Derivative Type Unifying Some Fractional Derivative Types with Classical Properties

, 2018
We introduce a truncated $M$-fractional derivative type for $\alpha$-differentiable functions that generalizes four other fractional derivatives types recently introduced by Khalil et al., Katugampola and Sousa et al., the so-called conformable ...
J. Vanterler da C. Sousa, E. Capelas de Oliveira   +1 more
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