Results 251 to 260 of about 2,052,042 (321)

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

[Formula: see text] model for analyzing [Formula: see text]-19 pandemic process via [Formula: see text]-Caputo fractional derivative and numerical simulation. [PDF]

Sci Rep
Mohammadaliee B, Roomi V, Samei ME.
europepmc   +1 more source

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A new study on the mathematical modelling of human liver with Caputo–Fabrizio fractional derivative

Chaos, Solitons and Fractals, 2020
In this research, we aim to propose a new fractional model for human liver involving Caputo–Fabrizio derivative with the exponential kernel. Concerning the new model, the existence of a unique solution is explored by using the Picard–Lindelof approach ...
D. Baleanu, A. Jajarmi, H. Mohammadi, S. Rezapour   +3 more
semanticscholar   +3 more sources

Convex Fractional Derivative

SSRN Electronic Journal
M. Benbachir
semanticscholar   +2 more sources

Two compartmental fractional derivative model with general fractional derivative

Journal of Pharmacokinetics and Pharmacodynamics, 2022
This study presents a new two compartmental model with, recently defined General fractional derivative. We review that concept of General fractional derivative and use the kernel function that generalizes the classical Caputo derivative in a mathematically consistent way.
Vesna Miskovic-Stankovic, Marko Janev, Teodor M. Atanackovic   +2 more
openaire   +2 more sources

Operational Calculus for the General Fractional Derivative and Its Applications

Fractional Calculus and Applied Analysis, 2021
In this paper, we first address the general fractional integrals and derivatives with the Sonine kernels that possess the integrable singularities of power function type at the point zero.
Yuri Luchko
semanticscholar   +1 more source