Results 51 to 60 of about 34,631 (216)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Two Integral Representations for the Relaxation Modulus of the Generalized Fractional Zener Model
Fractal and Fractional, 2023 A class of generalized fractional Zener-type viscoelastic models with general fractional derivatives is considered. Two integral representations are derived for the corresponding relaxation modulus. The first representation is established by applying the
Emilia Bazhlekova, Sergey Pshenichnov
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
New Approach for Fractional Order Derivatives: Fundamentals and Analytic Properties
Mathematics, 2016 The rate of change of any function versus its independent variables was defined as a derivative. The fundamentals of the derivative concept were constructed by Newton and l’Hôpital.
Ali Karcı
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
e-Prime: Advances in Electrical Engineering, Electronics and EnergyThis paper investigates the impact of fractional derivatives on the activation functions of an artificial neural network (ANN). Based on the results and analysis, a three-layer backpropagation neural network model with fractional and integer derivatives ...
Manisha Premkumar Joshi +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
On Riemann-Liouville and Caputo Derivatives
Discrete Dynamics in Nature and Society, 2011 Recently, many models are formulated in terms of fractional derivatives, such as in control processing, viscoelasticity, signal processing, and anomalous diffusion. In the present paper, we further study the important properties of the Riemann-Liouville (
Changpin Li, Deliang Qian, YangQuan Chen
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Abstract and Applied Analysis, 2014 We study fractional-order derivatives of left-handed Grünwald-Letnikov formula with ...
Shaoxiang Hu, Ping Liang
doaj +1 more source