Results 51 to 60 of about 184,534 (322)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Fractional Differential Equations 2012

open access: yesInternational Journal of Differential Equations, 2013
Journal of Differential Equations dédié aux équations différentielles fractionnaires (FDE). Ces dernières années, un nombre croissant d'articles rédigés par de nombreux auteurs de divers domaines de la science et de l'ingénierie traitent de systèmes dynamiques décrits par des équations aux dérivées partielles fractionnaires.
Fawang Liu   +4 more
openaire   +4 more sources

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

A Novel Iterative Method for Solving Systems of Fractional Differential Equations

open access: yesJournal of Applied Mathematics, 2013
The Reconstruction of Variational Iteration Method (RVIM) technique has been successfully applied to obtain solutions for systems of nonlinear fractional differential equations: , ,  , , where denote Caputo fractional derivative.
E. Hesameddini, A. Rahimi
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The G′G-expansion method using modified Riemann–Liouville derivative for some space-time fractional differential equations

open access: yesAin Shams Engineering Journal, 2014
In this paper, the fractional partial differential equations are defined by modified Riemann–Liouville fractional derivative. With the help of fractional derivative and traveling wave transformation, these equations can be converted into the nonlinear ...
Ahmet Bekir, Özkan Güner
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Computational Solution of a Fractional Integro-Differential Equation

open access: yesAbstract and Applied Analysis, 2013
Although differential transform method (DTM) is a highly efficient technique in the approximate analytical solutions of fractional differential equations, applicability of this method to the system of fractional integro-differential equations in higher ...
Muhammet Kurulay   +2 more
doaj   +1 more source

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