Results 191 to 200 of about 8,717 (246)

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell, EarlyView.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
wiley   +1 more source

Outcomes from Quantitative Flow Ratio-Guided Complete Revascularization and Angiography-Guided Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction. [PDF]

Med Sci Monit
Krivickas Ž, Barauskas M, Jodka N, Žiubrytė G, Pranevičius R, Unikas R.   +5 more
europepmc   +1 more source

Aerobic Exercise Attenuates Autophagy‐Lysosomal Flux Deficits via β2‐AR‐Mediated ESCRT‐III Subunit CHMP4B in Mice With Human MAPT P301L

Aging Cell, EarlyView.
MAPT accumulation inhibited CHMP4B expression and thus disrupted ESCRT‐III‐mediated autophagosome‐lysosome fusion, which induced a vicious cycle between MAPT aggregation and autophagic deficits. Aerobic exercise could effectively block the vicious cycle and reverse autophagic deficits by promoting the β2‐AR‐RXRα‐CHMP4B‐ESCRT‐III pathway, reducing ...
Shu‐Guang Bi, Haitao Yu, Tian‐Long Gao, Jia‐Jun Wu, Yu‐Ming Mao, Juan Gong, Fang‐Zhou Wang, Liu Yang, Jia Chen, Zi‐Chong Lan, Meng‐Ting Shen, Yun‐Juan Nie, Gao‐Shang Chai   +12 more
wiley   +1 more source

Impact of myocardial scar burden on microvascular resistance reserve in patients with coronary artery disease. [PDF]

Eur J Nucl Med Mol Imaging
Hoshino M, Hoek R, Jukema RA, Dahdal J, van Diemen P, Hopman LHGA, Raijmakers P, Driessen R, Twisk J, Danad I, Kakuta T, Knuuti J, Knaapen P.   +12 more
europepmc   +1 more source

Rare but relevant: Cannabis use and myocardial infarction

Addiction, EarlyView.
Abstract Pre‐clinical research and case reports have linked cannabis use to myocardial infarction (MI) since the 1970s. The association with MI may be specific to certain types and patterns of cannabis use as well as certain consumer characteristics; however, due to limited data availability, meta‐analyses examining the association between cannabis use
Prianka Padmanathan, Emmert Roberts
wiley   +1 more source

Impact of Systematic Use of Fractional Flow Reserve and Optical Coherence Tomography on Percutaneous Coronary Intervention Outcomes in Patients With Diabetes. [PDF]

Cardiol Res
Bahuleyan CG, Sethuraman S, Malik FT, Kasturi S, Chopda MB, Kadavil RM, Kapoor R, Roy S, Abhaichand R, Menon A, Subban V.   +10 more
europepmc   +1 more source

Total Neoadjuvant Therapy Versus Conventional Neoadjuvant Therapy for Rectal Cancer: Cost Analysis in a Public Healthcare System

ANZ Journal of Surgery, EarlyView.
Costs of neoadjuvant therapy. ABSTRACT Purpose Total neoadjuvant therapy (TNT) has become the standard of care in locally advanced rectal cancer, but its economic impact is unclear. This study compares the cost of TNT with conventional neoadjuvant therapy (CNT), consisting of either short‐course radiotherapy or long‐course chemoradiotherapy, within a ...
Ishraq Murshed, Sergei Bedrikovetski, Ishmam Murshed, Zachary Bunjo, Tracy Fitzsimmons, Michelle Thomas, Tarik Sammour   +6 more
wiley   +1 more source

Advanced cardiac magnetic resonance imaging for assessment of obstructive coronary artery disease-ADVOCATE-CMR study rationale and design. [PDF]

J Cardiovasc Magn Reson
Borodzicz-Jazdzyk S, de Mooij GW, den Hartog AW, Hofman MBM, Götte MJW.   +4 more
europepmc   +1 more source

The Application of Artificial Intelligence and Machine Learning in Left Ventricular Assist Device Implantation: A Systematic Review

Artificial Organs, EarlyView.
This systematic review explores the application of artificial intelligence and machine learning in left ventricular assist device implantation, highlighting their superior accuracy in predicting mortality, adverse events, myocardial recovery, thrombosis risk, and right ventricular failure. Despite promising outcomes, challenges like data heterogeneity,
Usama Hussain, Wing Kiu Chou, Abhinav Balasubramanian, Jamolbi Rahmatova, Lydia Wilkinson, Arian Arjomandi Rad, Ioannis Dimarakis, Antonios Kourliouros   +7 more
wiley   +1 more source

Comparative efficacy of intravascular ultrasound and fractional flow reserve in guiding percutaneous coronary intervention. [PDF]

Medicine (Baltimore)
Wu H, Wu X, Yu W, Wang H, Tan B, Hou L, Xu J.   +6 more
europepmc   +1 more source