Results 191 to 200 of about 26,752 (329)

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study. [PDF]

Circulation
Ahmed-Jushuf F, Foley MJ, Chotai S, Rajkumar CA, Wang D, Simader FA, Macierzanka K, Chiew K, Misra S, Williams R, Konstantinou K, Din JN, Mohdnazri SR, O'Kane PD, Haworth P, Nijjer SS, Seligman H, Keeble TR, Davies JR, Clesham G, Hinton J, Spratt JC, Dungu JN, Knight D, Kotecha T, Harrell FE, Howard JP, Francis DP, Shun-Shin MJ, Al-Lamee RK.   +29 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Vessel-Specific Differences in Fractional Flow Reserve Among Intermediate Coronary Lesions. [PDF]

J Clin Med
Weerts V, Davidsen C, Lempereur M, Marechal P, Davin L, Martinez C, Lancellotti P.   +6 more
europepmc   +1 more source

A review of the relationship between dimensions of alcohol consumption and the burden of disease: 2026 update including Mendelian randomisation studies

Addiction, EarlyView.
Abstract Background and aims Evidence on the causal impact and corresponding risk relationships between dimensions of alcohol consumption and health outcomes continues to evolve, with some contradictory findings across study designs. This review aimed to update current knowledge on causality and risk relationships to inform global and national ...
Sinclair Carr, Ana Lucia Espinosa Dice, Gerhard E. Gmel Sr., Ahmed S. Hassan, Kevin D. Shield, Jürgen Rehm   +5 more
wiley   +1 more source

Prognostic value of CT-derived fractional flow reserve for major adverse cardiovascular events in patients with suspected or known coronary artery disease: a systematic review and meta-analysis. [PDF]

Open Heart
Biswas S, Srivastava Y, Hamadttu A.
europepmc   +1 more source

Comparison of Intraoperative Doppler Flow Measurements and Algorithmic Flow Estimations in Patients Undergoing Durable Left Ventricular Assist Device Implantation

Artificial Organs, EarlyView.
Direct intraoperative HeartMate 3 LVAD flow measurements using an ultrasonic probe revealed consistently higher values by approximately 0.5 L/min compared to device‐estimated flows. This discrepancy remained stable across pump speed settings, highlighting the importance of distinguishing measured from estimated flow in HeartMate 3 patients.
Gaik Nersesian, Anna Stegmann, Daniel Lewin, Yuriy Hrytsyna, Leonard Pitts, Julius Kaemmel, Marian Kukucka, Alexander Mladenow, Lisa Garczarek, Julia Stein, Friedrich Kaufmann, Volkmar Falk, Evgenij Potapov, Pia Lanmueller   +13 more
wiley   +1 more source

Multimodality Assessment of a Culprit LAD Myocardial Bridge in a Patient With Congenital Heart Disease. [PDF]

JACC Case Rep
Singh S, Ravipati G, Mann H, Uppu S, Mallula K, Ramzy D, Gregoric ID, Kar B, Basra SS.   +8 more
europepmc   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Ischaemic cardiomyopathy with a significant improvement in left ventricular wall motion following revascularization for a honeycomb-like structure of the left anterior descending artery: a case report. [PDF]

Eur Heart J Case Rep
Yoshikawa H, Hanyu Y, Onishi Y, Yonetsu T, Sasano T.   +4 more
europepmc   +1 more source