Results 121 to 130 of about 1,761,784 (288)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Fractional Integral Inequalities of Gruss Type via Generalized Mittag-Leffler Function

International Journal of Analysis and Applications, 2019
We use generalized fractional integral operator containing the generalized Mittag-Leffler function to establish some new integral inequalities of Gr¨uss type. A cluster of fractional integral inequalities have been identified by setting particular values
G. Farid, A. U. Rehman, Vishnu Narayan Mishra, S. Mehmood   +3 more
doaj   +2 more sources

Weighted inequalities for multilinear fractional integral operators

Collectanea mathematica, 2009
The author considers fractional multilinear integral operators \[ {\mathcal I}_\alpha \vec{f}(x):= \int_{\left({\mathbb R}^n\right)^m } {f_1(y_1) \cdots f_m(y_m)\over \left(|x-y_1|+\dots+|x-y_m|\right)^{nm-\alpha}} d\vec{y}. \] Sufficient conditions for the two weight inequalities \[ \left(\int_{{\mathbb R}^n} (|{\mathcal I}_\alpha\vec{f}|u)^q dx\right)
openaire   +3 more sources

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

CHOQUET INTEGRALS, HAUSDORFF CONTENT AND FRACTIONAL OPERATORS

Bulletin of the Australian Mathematical Society
AbstractWe show that the fractional integral operator $I_{\alpha }$ , $0<\alpha <n$ , and the fractional maximal operator $M_{\alpha }$ , $0\le \alpha <n$ , are bounded on weak Choquet spaces with respect to Hausdorff content. We also investigate these operators on Choquet–Morrey spaces. The results for the fractional maximal operator $M_\
Hatano, Naoya, Kawasumi, Ryota, Saito, Hiroki, Tanaka, Hitoshi   +3 more
openaire   +3 more sources

On a Hardy’s inequality for a fractional integral operator

, 2018
In the present work we find inequalities that generalize some results found by Iqbal in [4, 5] regarding Riemann-Liouville fractional integral, by means of a Hardy inequality, using fractional integral operators defined by R.K. Raina in [9]
Vivas Cortez, Miguel José
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source