Results 101 to 110 of about 238,951 (299)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Fractional fundamental lemma and fractional integration by parts formula -- Applications to critical points of Bolza functionals and to linear boundary value problems

open access: yes, 2015
In the first part of the paper, we prove a fractional fundamental (du Bois-Reymond) lemma and a fractional variant of the integration by parts formula. The proof of the second result is based on an integral representation of functions possessing Riemann ...
Bourdin, Loïc, Idczak, Dariusz
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Numerical solution of fractional Mathieu equations by using block-pulse wavelets

open access: yesJournal of Ocean Engineering and Science, 2019
In this paper, we introduce a method based on operational matrix of fractional order integration for the numerical solution of fractional Mathieu equation and then apply it in a number of cases.
P. Pirmohabbati   +3 more
doaj   +1 more source

Infant mortality rates: Time trends and fractional integration [PDF]

open access: yes, 2011
This paper examines the time trends in infant mortality rates in a number of countries in the 20th century. Rather than imposing that the error term is a stationary I(0) process, we allow for the possibility of fractional integration and hence for a much
Caporale, GM, Gil-Alana, LA
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Dynamic Factor Models and Fractional Integration—With an Application to US Real Economic Activity

open access: yesEconometrics
This paper makes a twofold contribution. First, it develops the dynamic factor model of by allowing for fractional integration instead of imposing the classical dichotomy between I(0) stationary and I(1) non-stationary series.
Guglielmo Maria Caporale   +2 more
doaj   +1 more source

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