Results 131 to 140 of about 2,362 (222)

Asymmetric critical fractional p-Laplacian problems

open access: yesElectronic Journal of Differential Equations, 2017
We consider the asymmetric critical fractional p-Laplacian problem $$\displaylines{ (-\Delta)^s_p u = \lambda |u|^{p-2} u + u^{p^\ast_s - 1}_+,\quad \text{in } \Omega;\cr u = 0, \quad \text{in } \mathbb{R}^N\setminus\Omega; }$$ where $\lambda>0 ...
Li Huang, Yang Yang
doaj  

A Novel Approach to the Fractional Laplacian via Generalized Spherical Means

open access: yesFractal and Fractional
Although at least ten equivalent definitions of the fractional Laplacian exist in unbounded domains, we introduce an additional equivalent definition based on the generalized spherical mean-value operator—a Fourier multiplier operator involving the ...
Fethi Bouzeffour
doaj   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses for Ubrogepant Efficacy and Safety in the Acute Treatment of Migraine: Analysis of Phase 1–3 Studies

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 6, June 2026.
Abstract A population pharmacokinetic (popPK) model was developed for ubrogepant using data from 10 Phase 1, 1 Phase 2, and 2 Phase 3 studies. The data were described by a 2‐compartment model with linear elimination and transit compartment absorption. Formulation, food intake, race, gender, and hepatic impairment had a statistically significant impact ...
Sven Stodtmann   +3 more
wiley   +1 more source

Progress in Natural Products Target Discovery Technology

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan   +7 more
wiley   +1 more source

Matsumura‐Type Estimates and Global Solutions of a Fractional Wave Equation With Nonlocal Nonlinearity

open access: yesMathematical Methods in the Applied Sciences, Volume 49, Issue 9, Page 9967-9983, June 2026.
ABSTRACT The main results of this paper are the global existence and long time behavior of solutions of a fractional wave equation with a nonlocal nonlinearity. The techniques in this work rely on norm estimates of the solutions of εutt+ut+(−Δ)βu=0,u(0,x)=φ(x),ut(0,x)=ψ(x),$$ \varepsilon {u}_{tt}+{u}_t+{\left(-\Delta \right)}^{\beta }u=0,\kern1em u ...
Ibrahim Ahmad Suleman, Mokhtar Kirane
wiley   +1 more source

Existence of solutions for non-local elliptic systems with Hardy-Littlewood-Sobolev critical nonlinearities

open access: yesElectronic Journal of Differential Equations, 2019
In this work, we establish the existence of solutions for the nonlinear nonlocal system of equations involving the fractional Laplacian, \begin{gather*} \begin{aligned} (-\Delta)^s u & = au+bv+\frac{2p}{p+q}\int_{\Omega}\frac{|v(y)|^q}{|x-y|^\mu}dy|
Yang Yang, Qian Yu Hong, Xudong Shang
doaj  

Input Layer Regularization and Automated Regularization Hyperparameter Tuning for Myelin Water Estimation Using Deep Learning

open access: yesNMR in Biomedicine, Volume 39, Issue 6, June 2026.
We propose a novel deep learning algorithm for predicting the myelin water fraction from multiple gradient‐echo or spin‐echo pulse sequences arising in magnetic resonance relaxometry (MRR) measurements of the human brain. Our method incorporates both regularized nonlinear least squares and pure deep learning through a concatenation paradigm known as ...
Mirage Modi   +7 more
wiley   +1 more source

The properties of a new fractional g-Laplacian Monge-Ampère operator and its applications

open access: yesAdvances in Nonlinear Analysis
In this article, we first introduce a new fractional gg-Laplacian Monge-Ampère operator: Fgsv(x)≔infP.V.∫Rngv(z)−v(x)∣C−1(z−x)∣sdz∣C−1(z−x)∣n+s∣C∈C,{F}_{g}^{s}v\left(x):= \inf \left\{\hspace{0.1em}\text{P.V.}\hspace{0.1em}\mathop{\int }\limits_{{{\mathbb{
Wang Guotao, Yang Rui, Zhang Lihong
doaj   +1 more source

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