Results 91 to 100 of about 176,088 (217)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A study on the existence of unique stable approximate solutions: fractal-fractional-based model of an energy supply–demand system

Boundary Value Problems
We investigate a fractional energy supply–demand system (ES–DS) model using power-law-type kernels and advanced operators called fractal-fractional operators with a couple of fractal and fractional orders.
Salah Boulaaras, Tanzeela Kanwal, İbrahim Avcı, Sina Etemad, Zaher Mundher Yaseen   +4 more
doaj   +1 more source

Studying of COVID-19 fractional model: Stability analysis. [PDF]

Partial Differ Equ Appl Math, 2023
Khalaf SL, Kadhim MS, Khudair AR.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Fractional Model Reference Adaptive PIλDμ Control

Journal of New Results in Science, 2016
This study explains the auto-adjustable fractional order the proportional–integral–derivative (PID) controller design methodology by using the technique of fractional model reference adaptive control (fractional MRAC).
Hüseyin Arpacı, Ömerül Faruk Özgüven, Mehmet Serhat Can   +2 more
doaj  

A time fractional model of a Maxwell nanofluid through a channel flow with applications in grease. [PDF]

Sci Rep, 2023
Khan N, Ali F, Ahmad Z, Murtaza S, Ganie AH, Khan I, Eldin SM.   +6 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Influence of Fractional Order on the Behavior of a Normalized Time-Fractional SIR Model

Mathematics
In this paper, we propose a novel normalized time-fractional susceptible–infected–removed (SIR) model that incorporates memory effects into epidemiological dynamics.
Junseok Kim
doaj   +1 more source

A novel fractional model for the projection of households using wealth index quintiles. [PDF]

PLoS One, 2022
Ahmad S, Javeed S, Raza S, Baleanu D.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source