Results 51 to 60 of about 1,637 (213)

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

Spheres, tears, and spears: Regulating the perimeter and circularity of millimeter‐sized alginate hydrogel beads

AIChE Journal, EarlyView.
Abstract Generating hydrogel beads pertains to many engineering applications. We examined two alginate‐based fluids at three concentrations of alginate, cAG$$ {c}_{\mathrm{AG}} $$. We used the “Map of Misery” to determine which material property (viscosity, elasticity, and inertia) drives droplet formation.
Conor G. Harris, Katherine D. Bandettini, Hannah K. Gedde, Lewis Semprini, Kaitlin C. Fogg, Willie E. Rochefort   +5 more
wiley   +1 more source

The Uniqueness of Solution for a Class of Fractional Order Nonlinear Systems with p-Laplacian Operator

Abstract and Applied Analysis, 2014
We are concerned with the uniqueness of solutions for a class of p-Laplacian fractional order nonlinear systems with nonlocal boundary conditions.
Jun-qi He, Xue-li Song
doaj   +1 more source

Lyapunov-type inequalities for a fractional p-Laplacian equation [PDF]

Journal of Inequalities and Applications, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Al Arifi, Nassir, Altun, Ishak, Jleli, Mohamed, Lashin, Aref, Samet, Bessem   +4 more
openaire   +2 more sources

Upsampling DINOv2 Features for Unsupervised Vision Tasks and Weakly Supervised Materials Segmentation

Advanced Intelligent Systems, EarlyView.
Feature from recent image foundation models (DINOv2) are useful for vision tasks (segmentation, object localization) with little or no human input. Once upsampled, they can be used for weakly supervised micrograph segmentation, achieving strong results when compared to classical features (blurs, edge detection) across a range of material systems.
Ronan Docherty, Antonis Vamvakeros, Samuel J. Cooper   +2 more
wiley   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Nonlinear commutators for the fractional p-Laplacian and applications [PDF]

Mathematische Annalen, 2015
We prove a nonlocal, nonlinear commutator estimate concerning the transfer of derivatives onto testfunctions. For the fractional $p$-Laplace operator it implies that solutions to certain degenerate nonlocal equations are higher differentiable. Also, weak fractional $p$-harmonic functions which a priori are less regular than variational solutions are in
openaire   +5 more sources

Pharmacokinetics and pharmacodynamics of intravenous and oral (S)‐ketamine: Investigating metabolite contribution to subjective effects

British Journal of Clinical Pharmacology, EarlyView.
Aims Oral administration of (S)‐ketamine for treatment‐resistant depression (TRD), as alternative to the registered intranasal or off‐label intravenous administrations, has high potential. However, it is characterized by an extensive first‐pass metabolism, resulting in low (S)‐ketamine exposure and high levels of active metabolites, including (S ...
Marije E. Otto, Gabriël E. Jacobs, Joost C. van Mechelen, Laura G. J. M. Borghans, Johan G. C. van Hasselt, Linda B. S. Aulin   +5 more
wiley   +1 more source

Local Polynomial Regression and Filtering for a Versatile Mesh‐Free PDE Solver

International Journal for Numerical Methods in Fluids, EarlyView.
A high‐order, mesh‐free finite difference method for solving differential equations is presented. Both derivative approximation and scheme stabilisation is carried out by parametric or non‐parametric local polynomial regression, making the resulting numerical method accurate, simple and versatile. Numerous numerical benchmark tests are investigated for
Alberto M. Gambaruto
wiley   +1 more source

Global existence and blow-up of weak solutions for a class of fractional p-Laplacian evolution equations

Advances in Nonlinear Analysis, 2020
In this paper, we study the fractional p-Laplacian evolution equation with arbitrary initial energy,
Liao Menglan, Liu Qiang, Ye Hailong
doaj   +1 more source