Results 61 to 70 of about 6,558 (265)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Homotopy Perturbation Method Combined with ZZ Transform to Solve Some Nonlinear Fractional Differential Equations

International Journal of Analysis and Applications, 2019
The idea proposed in this work is to extend the ZZ transform method to resolve the nonlinear fractional partial differential equations by combining them with the so-called homotopy perturbation method (HPM).
Lakhdar Riabi, Kacem Belghaba, Mountassir Hamdi Cherif, Djelloul Ziane   +3 more
doaj   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Global Stability for Fractional Diffusion Equations in Biological Systems

Complexity, 2020
This paper proposes a new method of construction of Lyapunov functionals for the dynamical systems described by fractional differential equations and fractional partial differential equations. The proposed method is rigorously presented. Furthermore, the
Khalid Hattaf, Noura Yousfi
doaj   +1 more source

Domain decomposition methods for space fractional partial differential equations [PDF]

Journal of Computational Physics, 2017
In this paper, a two-level additive Schwarz preconditioner is proposed for solving the algebraic systems resulting from the finite element approximations of space fractional partial differential equations (SFPDEs). It is shown that the condition number of the preconditioned system is bounded by C(1+H/δ), where H is the maximum diameter of subdomains ...
Jiang, Yingjun, Xu, Xuejun
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Solving Fractional Partial Differential Equations with Corrected Fourier Series Method

Abstract and Applied Analysis, 2014
The corrected Fourier series (CFS) is proposed for solving partial differential equations (PDEs) with fractional time derivative on a finite domain. In the previous work, we have been solving partial differential equations by using corrected Fourier ...
Nor Hafizah Zainal, Adem Kılıçman
doaj   +1 more source

Fractional Partial Random Differential Equations with State-Dependent Delay [PDF]

Annals of West University of Timisoara - Mathematics and Computer Science, 2017
Abstract In the present paper we provide some existence results for the Darboux problem of partial fractional random differential equations with state-dependent delay by applying the measure of noncompactness and a random fixed point theorem with stochastic domain.
Benchohra Mouffak, Heris Amel
openaire   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source