Results 241 to 250 of about 735,801 (358)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Phase equilibria modelling of trace element evolution in arc magmas: implications for petrogenesis and copper porphyry indicators. [PDF]

Contrib Mineral Petrol
Soderman CR, Weller OM.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Comparison of Spatio-Temporal Dynamics and Composition in Size-Fractionated and Unfractionated Northwestern Atlantic Microbial Communities. [PDF]

Environ Microbiol Rep
Haider D, Tolman J, Beiko RG, LaRoche J.
europepmc   +1 more source

Molybdenum isotope fractionation in the mantle [PDF]

, 2013
Burton, K. W., Fitton, J. G., Halliday, A. N., Liang, Y.-H., Siebert, Christopher   +4 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A Unified Method for Triple Oxygen Isotope Analysis of Sulfate, Water, and Organics. [PDF]

Anal Chem
Zahnow F, Feng D, Pack A, Bajnai D, Herwartz D.   +4 more
europepmc   +1 more source

Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain

, 2008
Giovanni Lugli, Vetle I. Torvik, John Larson, Neil R. Smalheiser   +3 more
openalex   +2 more sources

Fraction Collectors [PDF]

Science, 1975
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source