Results 41 to 50 of about 427,015 (306)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Petroleum, 2021 The mode-I fracture toughness is of great significance for evaluating the fracturing ability of shale reservoirs. In this study, the mode-I fracture toughness of the shale in the Lower Silurian Longmaxi Formation, Southern Sichuan Basin was determined ...
Jian Xiong +4 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
JBMR Plus, 2023 Older women with a first hip fracture exhibit heightened susceptibility and incidence of second fracture and potentially severe consequences. This prospective study was to compare the predictive power of qualitative and quantitative muscle parameters for
Wenshuang Zhang +14 more
doaj +1 more source
Study on coalbed methane flow characteristics based on fracture network image
Meikuang Anquan, 2021 The natural fracture network developed in coal body is the main channel for gas migration. It is of great significance to study the influence of the geometric characteristics of fracture network on CBM flow characteristics.
ZHANG Yuzhu
doaj +1 more source
Properties of nanostructured diamond-silicon carbide composites sintered by high pressure infiltration technique [PDF]
, 2004 A high-pressure silicon infiltration technique was applied to sinter diamond–SiC composites with different diamond crystal sizes. Composite samples were sintered at pressure 8 GPa and temperature 2170 K.
G.A. Voronin +12 more
core +2 more sources
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]
, 2006 BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Ale Algra +14 more
core +8 more sources
Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma +9 more
wiley +1 more source
Energies, 2017 This paper presents an integrated approach of discrete fracture network modelling for a naturally fractured buried-hill carbonate reservoir in the Jingbei Oilfield by using a 3D seismic survey, conventional well logs, and core data.
Junling Fang, Fengde Zhou, Zhonghua Tang
doaj +1 more source