Results 31 to 40 of about 220,477 (344)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Fracture Mechanics: Inspirations from Nature [PDF]

Fracture and Structural Integrity, 2014
In Nature there are many examples of materials performing structural functions. Nature requires materials which are stiff and strong to provide support against various forces, including self-weight, the dynamic forces involved in movement, and external ...
David Taylor
doaj   +2 more sources

Crack propagation modeling of strengthening reinforced concrete deep beams with CFRP plates

Materials Research Express, 2021
Fracture analysis of reinforced concrete deep beam strengthened with carbon fiber-reinforced polymer (CFRP) plates was carried out. The present research aimed to discover whether crack propagation in a strengthened deep beam follows linear elastic ...
Shahriar Shahbazpanahi, Hogr Karim, Wrya Abdullah, Uwe Reuter, Amir H Mosavi   +4 more
doaj   +1 more source

Fracture toughness testing data: A technology survey and bibliography [PDF]

, 1975
Announced survey includes reports covering fracture toughness testing for various structural materials including information on plane strain and developing areas of mixed mode and plane strain test conditions.
Carpenter, J. L., Jr., Mandel, G., Moya, N., Stuhrke, W. F.   +3 more
core   +1 more source

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source

Study on Elastic-plastic fracture mechanics assessment method of a pipe having multiple circumferential surface cracks for the Rules on Fitness-for-Service of JSME

Nihon Kikai Gakkai ronbunshu, 2019
This paper describes elastic-plastic fracture mechanics assessment methods of a pipe having multiple circumferential cracks. Ductile fracture strength of a multiple cracked pipe was evaluated using J-integral based on a reference stress method.
Hideo MACHIDA, Toshiki OKAMOTO, Shinji YOSHIDA   +2 more
doaj   +1 more source

Hip Morphology–Based Osteoarthritis Risk Prediction Models: Development and External Validation Using Individual Participant Data From the World COACH Consortium

Arthritis Care &Research, EarlyView.
Objective This study aims to develop hip morphology‐based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different populations. Methods We combined data from nine prospective cohort studies participating in the Worldwide Collaboration ...
Myrthe A. van den Berg, Fleur Boel, Michiel M. A. van Buuren, Noortje S. Riedstra, Jinchi Tang, Harbeer Ahedi, Nigel K. Arden, Sita M. A. Bierma‐Zeinstra, Cindy G. Boer, Flavia M. Cicuttini, Timothy F. Cootes, David T. Felson, Willem Paul Gielis, Joshua Heerey, Graeme Jones, Stefan Kluzek, Nancy E. Lane, Claudia Lindner, Joyce B. J. van Meurs, Andrea Mosler, Amanda E. Nelson, Michael C. Nevitt, Edwin H. Oei, Jos Runhaar, Harrie Weinans, Jesse H. Krijthe, Rintje Agricola   +26 more
wiley   +1 more source

Linear elastic fracture mechanics predicts the propagation distance of frictional slip [PDF]

, 2014
When a frictional interface is subject to a localized shear load, it is often (experimentally) observed that local slip events initiate at the stress concentration and propagate over parts of the interface by arresting naturally before reaching the edge.
Ampuero, Jean-Paul, Kammer, David S., Molinari, Jean-François, Radiguet, Mathilde   +3 more
core   +2 more sources

Adipokines and Associations With Incident Osteoporotic Fracture in Patients With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, and fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source

Experimental and theoretical investigation of the influence of post-curing on mixed mode fracture properties of 3d-printed polymer samples

Scientific Reports
This study explores the mechanical properties and fracture characteristics of additively manufactured acrylonitrile butadiene styrene specimens, focusing on the impact of raster angle and post-process heat treatment.
Bahador Bahrami, Hossein Talebi, M. M. Momeni, M. R. Ayatollahi   +3 more
doaj   +1 more source