Results 31 to 40 of about 3,896,033 (287)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Multiscale modelling of materials chemomechanics : brittle fracture of oxides and semiconductors [PDF]

, 2014
Fracture is one of the most challenging ‘multi-scale’ problems to model: since crack propagation is driven by the concentration of a long-range stress field at an atomically sharp crack tip, an accurate description of the chemical processes occurring in ...
De Vita, Alessandro, Peralta, Giovanni, Li, Zhenwei, Kermode, James, Kermode, James R.   +4 more
core   +1 more source

Epidemiological characterization of tibial plateau fractures

Journal of Orthopaedic Surgery and Research, 2022
Background Tibial plateau fractures are traumatic injuries with severities ranging from nondisplaced to complicated fractures. This study describes the epidemiological characteristics of patients with tibial plateau fractures treated in five trauma ...
Juan Reátiga Aguilar, Ximena Rios, Eduardo González Edery, Alfredo De La Rosa, Laura Arzuza Ortega   +4 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Hot ductility and fracture mechanism of Fe-22Mn-0.7C TWIP steel

工程科学学报, 2016
The static tensile behaviors of Fe-22Mn-0.7C TWIP steel and Q235 steel between 700 ℃ and 1300 ℃ were investigated by Gleeble-1500 thermo-mechanical simulator.The microstructure characteristic and fracture morphology were observed by optical microscopy ...
LAN Peng, TANG Hai-yan, JI Yuan, DU Chen-wei, ZHANG Jia-quan   +4 more
doaj   +1 more source

Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs (VA) Rheumatoid Arthritis Registry. Frailty was measured using the VA Frailty Index (VAFI).
Katherine D. Wysham, Hannah F. Brubeck, Aaron Baraff, Punyasha Roul, Namrata Singh, James S. Andrews, Grant W. Cannon, Gary A. Kunkel, Ted R. Mikuls, Bryant R. England, Dolores M. Shoback, Patricia P. Katz, Jose M. Garcia, Ariela R. Orkaby, Joshua F. Baker   +14 more
wiley   +1 more source

Effect of Hatch Spacing on Microstructure, Defect Formation and Properties of Additively Manufactured A7075 Alloy

Metals
Understanding the mechanisms of microstructure evolution and defect formation, and their influence on mechanical properties and fracture mechanisms (from crack initiation to failure stage), is essential for manufacturing high-strength, fatigue-resistant ...
Adam Ismaeel, Zongxu Chen, Xuexiong Li, Xirui Jia, Ali Jamea, Xuanming Feng, Xiaohu Chen, Dongsheng Xu, Weining Lei   +8 more
doaj   +1 more source

On the Step Cooling Treatment for the Assessment of Temper Embrittlement Susceptibility of Heavy Forgings in Superclean Steels

Metals, 2016
When subjected to extended exposure to intermediate service temperatures, Cr–Mo steels, Ni–Cr steels, and 5% Ni steels can become embrittled, with an associated decrease in fracture toughness and a shift in the ductile-to-brittle transition temperature ...
Roberto Roberti, Michela Faccoli
doaj   +1 more source

Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo, Zahi Touma, Laura Whittall Garcia, Dafna D. Gladman, Behdin Nowrouzi‐Kia   +4 more
wiley   +1 more source