Fracture of an unnamed bone [PDF]
A 28-year-old professional footballer presented to the emergency department having sustained an isolated direct kick to the left shin with …
Baldeep Bains, Keith Porter
openaire +5 more sources
Simulating pharmaceutical treatment effects on osteoporosis via a bone remodeling algorithm targeting hypermineralized sites [PDF]
Pharmaceutical treatments can slow bone degradation, thus reducing the fracture risk inherent in osteoporosis. Antiresorptive treatments block the over-activation of osteoclasts vs osteoblasts, but the resulting decrease in bone remodeling frequency may weaken bone structure over time, with no gain in bone volume.
arxiv +1 more source
Thiazolidinediones and bone fractures [PDF]
The topic of increased risk of bone fracture associated with thiazolidinediones (TZD) treatment first drew international attention when a higher rate of fractures in women with diabetes treated with rosiglitazone was reported in the A Diabetes Outcome Program Trial (ADOPT)1. Subsequently, a number of clinical trials and observational studies addressing
Kohei Kaku, Mitsuru Hashiramoto
openaire +3 more sources
Cellular and molecular mediators of bone metastatic lesions [PDF]
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia+3 more
core +5 more sources
Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis [PDF]
Objectives: We aimed to assess the association between long-term use of inhaled corticosteroids (ICS) and bone adverse effects in patients with asthma. Design: Systematic review and meta-analysis of fracture risk and changes in bone mineral density with ...
Agertoft+32 more
core +1 more source
Investigation of the cellular response to bone fractures: evidence for flexoelectricity [PDF]
The recent discovery of bone flexoelectricity (electrical polarization induced by strain gradient) suggests that flexoelectricity could have physiological effects in bones, and specifically near bone fractures, where flexoelectricity is theoretically highest. Here, we report a cytological study of the interaction between crack stress and bone cells. We
arxiv +1 more source
Gray-level co-occurrence matrix bone fracture detection [PDF]
Problem statement: Currently doctors in orthopedic wards inspect the bone x-ray images according to their experience and knowledge in bone fracture analysis. Manual examination of x-rays has multitude drawbacks.
Ariff, A. K.+5 more
core +1 more source
Effects of Risedronate in Runx2 Overexpressing Mice, an Animal Model for Evaluation of Treatment Effects on Bone Quality and Fractures [PDF]
Young mice overexpressing Runx2 specifically in cells of the osteoblastic lineage failed to gain bone mass and exhibited a dramatic increase in bone resorption, leading to severe osteopenia and spontaneous vertebral fractures.
A. Ostertag+8 more
core +3 more sources
Experimental ex-vivo validation of PMMA-based bone cements loaded with magnetic nanoparticles enabling hyperthermia of metastatic bone tumors [PDF]
Percutaneous vertebroplasty comprises the injection of Polymethylmethacrylate (PMMA) bone cement into vertebrae and can be used for the treatment of compression fractures of vertebrae.
Crevecoeur, Guillaume+5 more
core +3 more sources
Increased sclerostin associated with stress fracture of the third metacarpal bone in the Thoroughbred Racehorse [PDF]
Objectives: The exact aetiopathogenesis of microdamage induced long bone fractures remains unknown. These fractures are likely the result of inadequate bone remodeling in response to damage.
Henson, F, Hopper, N, Singer, E
core +2 more sources