Results 241 to 250 of about 28,649 (270)
Some of the next articles are maybe not open access.
Fragile X Mental Retardation Protein: Past, Present and Future
Current Protein & Peptide Science, 2012We begin by reviewing the first characterization of fragile X syndrome, which ultimately led to cloning of the FMR1 gene. Discovery of the molecular basis of this disorder, including expansion of a trinucleotide repeat, gave insight not only into fragile X syndrome but also into the premutation syndromes.
Stephanie Ceman, Miri Kim
openaire +3 more sources
Distribution of fragile X mental retardation protein in the human auditory brainstem
Neuroscience, 2014Fragile X mental retardation protein (FMRP) binds select mRNAs, functions in intracellular transport of these mRNAs and represses their translation. FMRP is highly expressed in neurons and lack of FMRP has been shown to result in dendritic dysmorphology and altered synaptic function. FMRP is known to interact with mRNAs for the Kv3.1b potassium channel
Randy J. Kulesza, K. Beebe, Yuan Wang
openaire +2 more sources
The fragile X mental retardation protein, FMRP, recognizes G‐quartets
Mental Retardation and Developmental Disabilities Research Reviews, 2004AbstractFragile X mental retardation is a disease caused by the loss of function of a single RNA‐binding protein, FMRP. Identifying the RNA targets recognized by FMRP is likely to reveal much about its functions in controlling some aspects of memory and behavior.
Jennifer C. Darnell +4 more
openaire +3 more sources
Linking the fragile X mental retardation protein to the lipoxygenase pathway
Medical Hypotheses, 2013Fragile X mental retardation is caused by the absence of the FMRP (fragile X mental retardation protein) a RNA-binding protein encoded by the Fmr1 gene. Despite the large number of studies about this syndrome, it is still unclear how the absence of FMRP affects the physiology of the nervous system.
openaire +2 more sources
Biology of the fragile X mental retardation protein, an RNA-binding protein
Biochemistry and Cell Biology, 1999The fragile X syndrome, an X-linked disease, is the most frequent cause of inherited mental retardation. The syndrome results from the absence of expression of the FMR1 gene (fragile mental retardation 1) owing to the expansion of a CGG trinucleotide repeat located in the 5prime untranslated region of the gene and the subsequent methylation of its CpG
openaire +2 more sources
Review: Mental health impacts of the COVID‐19 pandemic on children and youth – a systematic review
Child and Adolescent Mental Health, 2022Hasina Samji, David Long
exaly