Results 111 to 120 of about 164,088 (328)
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
A five-valued logic and a system
Journal of Computer Science and Technology, 2004 The present article introduces a five-valued logic and a deductive system. Here, the logic presented is a relevant fragment of the @-logic, which is also a space-time logic. These five values correspond to the following semantics: unknown, possibly known
Ulisses Ferreira
doaj
Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor
Advanced Science, EarlyView.Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang +4 more
wiley +1 more source
Characterization of the axiomatizable prenex fragments of first-order Godel logics [PDF]
, 2004 Matthias Baaz +2 more
openalex +1 more source
Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution
Advanced Science, EarlyView.Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley +1 more source
Advanced Science, EarlyView.ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin +9 more
wiley +1 more source
Weak MSO: Automata and Expressiveness Modulo Bisimilarity
, 2014 We prove that the bisimulation-invariant fragment of weak monadic second-order logic (WMSO) is equivalent to the fragment of the modal $\mu$-calculus where the application of the least fixpoint operator $\mu p.\varphi$ is restricted to formulas $\varphi$
Carreiro, Facundo +3 more
core +1 more source
Fragments of Some Subintuitionistic Logics
In this article we determine the implicational fragments of most of the known subintuitionistic logics.
Maleki, Fatemeh Shirmohammadzadeh +1 more
openaire +2 more sources