A Golgi fragmentation pathway in neurodegeneration [PDF]
Neurobiology of Disease, 2008 The Golgi apparatus processes intracellular proteins, but undergoes disassembly and fragmentation during apoptosis in several neurodegenerative disorders such as amyotrophic lateral sclerosis and Alzheimer’s disease.
Saya Nakagomi +5 more
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Fragmentation Pathway of Organophosphorus Flame Retardants by Liquid Chromatography–Orbitrap-Based High-Resolution Mass Spectrometry [PDF]
MoleculesOrganophosphorus flame retardants (OPFRs) have been widely used in polymeric materials owing to their flame retardant and plasticizing effects. Investigating the fragmentation pathway of OPFRs is of great necessity for further discovering and identifying
Kangcong Li +5 more
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A machine learning approach to explore the spectra intensity pattern of peptides using tandem mass spectrometry data [PDF]
BMC Bioinformatics, 2008 Background A better understanding of the mechanisms involved in gas-phase fragmentation of peptides is essential for the development of more reliable algorithms for high-throughput protein identification using mass spectrometry (MS).
Feng Jianfeng, Bowler Lucas D, Zhou Cong
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Pathway from condensation via fragmentation to fermionization of cold bosonic systems [PDF]
Physical Review Letters, 2005 For small scattering lengths, cold bosonic atoms form a condensate the density profile of which is smooth. With increasing scattering length, the density {\it gradually} acquires more and more oscillations.
E. P. Gross +5 more
core +2 more sources
SENP3/FIS1-regulated PFC neural mitochondrial fragmentation underlies the mechanism of electroacupuncture attenuating depressive behavior in CUMS mice [PDF]
Frontiers in PsychiatryObjectiveElectroacupuncture (EA) is a common alternative treatment for depression, but its underlying mechanism remains unclear. Research suggests that its therapeutic effect may involve reducing SENP3/FIS1-regulated mitochondrial fragmentation, thereby ...
Shaoda Lai +13 more
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Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome‐autophagosome‐lysosome pathway dysfunction and microglia‐mediated neuroinflammation [PDF]
CNS Neuroscience & Therapeutics, 2019 Insufficient sleep has been found to result in varying degrees of cognitive impairment and emotional changes. Sleep was reported probably responsible for cleaning metabolic wastes in brain by increasing extracellular bulk flow.
Yi Xie +8 more
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αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]
Scientific Reports, 2017 The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Victorio Martin Pozo Devoto +12 more
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Molecular fragmentation as a crucial step in the AI-based drug development pathway
Communications ChemistryThe AI-based small molecule drug discovery has become a significant trend at the intersection of computer science and life sciences. In the pursuit of novel compounds, fragment-based drug discovery has emerged as a novel approach.
Shao Jinsong +4 more
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Dissection of Fragmentation Pathways in Protonated N-Acetylhexosamines. [PDF]
Analytical Chemistry, 2018 Structural characterization of carbohydrates by mass spectrometry necessitates a detailed understanding of their gas phase behavior, particularly for protonated carbohydrates that can undergo complex structural rearrangements during fragmentation.
A. Mookherjee, S. S. Uppal, M. Guttman
semanticscholar +3 more sources
Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway [PDF]
Cell Death and Differentiation, 2009 Géraldine Liot +5 more
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