Results 51 to 60 of about 79,992 (262)
Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourceEfficient Partitioning of Large Databases without Query Statistics [PDF]
Database Systems Journal, 2016 An efficient way of improving the performance of a database management system is distributed processing. Distribution of data involves fragmentation or partitioning, replication, and allocation process. Previous research works provided partitioning based Shahidul Islam KHANdoaj CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets +12 morewiley +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceInterplay among transversity induced asymmetries in hadron leptoproduction
Physics Letters B, 2016 In the fragmentation of a transversely polarized quark several left–right asymmetries are possible for the hadrons in the jet. When only one unpolarized hadron is selected, it exhibits an azimuthal modulation known as the Collins effect.C. Adolph, R. Akhunzyanov, M.G. Alexeev, G.D. Alexeev, A. Amoroso, V. Andrieux, V. Anosov, W. Augustyniak, A. Austregesilo, C.D.R. Azevedo, B. Badełek, F. Balestra, J. Barth, R. Beck, Y. Bedfer, J. Bernhard, K. Bicker, E.R. Bielert, R. Birsa, J. Bisplinghoff, M. Bodlak, M. Boer, P. Bordalo, F. Bradamante, C. Braun, A. Bressan, M. Büchele, E. Burtin, W.-C. Chang, M. Chiosso, I. Choi, S.-U. Chung, A. Cicuttin, M.L. Crespo, Q. Curiel, N. d'Hose, S. Dalla Torre, S.S. Dasgupta, S. Dasgupta, O.Yu. Denisov, L. Dhara, S.V. Donskov, N. Doshita, V. Duic, M. Dziewiecki, A. Efremov, C. Elia, P.D. Eversheim, W. Eyrich, A. Ferrero, M. Finger, M. Finger Jr., H. Fischer, C. Franco, N. du Fresne von Hohenesche, J.M. Friedrich, V. Frolov, E. Fuchey, F. Gautheron, O.P. Gavrichtchouk, S. Gerassimov, F. Giordano, I. Gnesi, M. Gorzellik, S. Grabmüller, A. Grasso, M. Grosse Perdekamp, B. Grube, T. Grussenmeyer, A. Guskov, F. Haas, D. Hahne, D. von Harrach, R. Hashimoto, F.H. Heinsius, F. Herrmann, F. Hinterberger, N. Horikawa, C.-Y. Hsieh, S. Huber, S. Ishimoto, A. Ivanov, Yu. Ivanshin, T. Iwata, R. Jahn, V. Jary, P. Jörg, R. Joosten, E. Kabuß, B. Ketzer, G.V. Khaustov, Yu.A. Khokhlov, Yu. Kisselev, F. Klein, K. Klimaszewski, J.H. Koivuniemi, V.N. Kolosov, K. Kondo, K. Königsmann, I. Konorov, V.F. Konstantinov, A.M. Kotzinian, O. Kouznetsov, M. Krämer, P. Kremser, F. Krinner, Z.V. Kroumchtein, N. Kuchinski, F. Kunne, K. Kurek, R.P. Kurjata, A.A. Lednev, A. Lehmann, M. Levillain, S. Levorato, J. Lichtenstadt, R. Longo, A. Maggiora, A. Magnon, N. Makins, N. Makke, G.K. Mallot, C. Marchand, B. Marianski, A. Martin, J. Marzec, J. Matousek, H. Matsuda, T. Matsuda, G. Meshcheryakov, W. Meyer, T. Michigami, Yu.V. Mikhailov, Y. Miyachi, P. Montuenga, A. Nagaytsev, F. Nerling, D. Neyret, V.I. Nikolaenko, J. Nový, W.-D. Nowak, G. Nukazuka, A.S. Nunes, A.G. Olshevsky, I. Orlov, M. Ostrick, D. Panzieri, B. Parsamyan, S. Paul, J.-C. Peng, F. Pereira, G. Pesaro, M. Pesek, D.V. Peshekhonov, S. Platchkov, J. Pochodzalla, V.A. Polyakov, J. Pretz, M. Quaresma, C. Quintans, S. Ramos, C. Regali, G. Reicherz, C. Riedl, N.S. Rossiyskaya, D.I. Ryabchikov, A. Rychter, V.D. Samoylenko, A. Sandacz, C. Santos, S. Sarkar, I.A. Savin, G. Sbrizzai, P. Schiavon, K. Schmidt, H. Schmieden, K. Schönning, S. Schopferer, A. Selyunin, O.Yu. Shevchenko, L. Silva, L. Sinha, S. Sirtl, M. Slunecka, F. Sozzi, A. Srnka, M. Stolarski, M. Sulc, H. Suzuki, A. Szabelski, T. Szameitat, P. Sznajder, S. Takekawa, J. ter Wolbeek, S. Tessaro, F. Tessarotto, F. Thibaud, F. Tosello, V. Tskhay, S. Uhl, J. Veloso, M. Virius, T. Weisrock, M. Wilfert, K. Zaremba, M. Zavertyaev, E. Zemlyanichkina, M. Ziembicki, A. Zink +208 moredoaj +1 more sourceStatistical models of fragmentation processes
Physics Letters B, 1974 Abstract A model with minimal correlations among nucleon momenta agrees well with refined data on fragment momentum distributions resulting from peripheral nucleus-nucleus collisions. The postulates are identical to those of Feshbach and Huang, but are applied to compute a quantity more relevant to expeeriment: the dependence of the momentum ...openaire +1 more sourceLongitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay +15 morewiley +1 more source