Results 41 to 50 of about 198,483 (281)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Double field theory and geometric quantisation

Journal of High Energy Physics, 2021
We examine various properties of double field theory and the doubled string sigma model in the context of geometric quantisation. In particular we look at T-duality as the symplectic transformation related to an alternative choice of polarisation in the ...
Luigi Alfonsi, David S. Berman
doaj   +1 more source

The Geometry of the Frame Bundle over Spacetime [PDF]

, 2000
One of the known mathematical descriptions of singularities in General Relativity is the b-boundary, which is a way of attaching endpoints to inextendible endless curves in a spacetime.
Ståhl, Fredrik
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The space of non-degenerate closed curves in a Riemannian manifold [PDF]

, 2012
Let LM be the semigroup of non-degenerate based loops with a fixed initial/final frame in a Riemannian manifold M of dimension at least three. We compare the topology of LM to that of the loop space Omega FTM on the bundle of frames in the tangent bundle
Mostovoy, Jacob, Sadykov, Rustam
core  

A Frame Bundle Generalization of Multisymplectic Momentum Mappings

, 2001
This paper presents generalized momentum mappings for covariant Hamiltonian field theories. The new momentum mappings arise from a generalization of symplectic geometry to $L_VY$, the bundle of vertically adapted linear frames over the bundle of field ...
Abraham, Fulp, Fulp, Gotay, Gotay, J.K Lawson, Kijowski, Kijowski, Kobayashi, Lawson, López, Marsden, McLean, Milnor, Nijenhuis, Norris, Norris, Norris, Norris, Schouten   +19 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Canonisation reper of complex of lines of theree-dimensional flag

Қарағанды университетінің хабаршысы. Математика сериясы, 2016
The paper studies the three-parameter geometric image of the line - a complex of line of three-dimensional space of the flag. It identifies the main forms that depend linearly on three basic parameters diferentials.
A.T. Musin
doaj   +1 more source

Rhythm disturbances following rapid-deployment aortic valve replacementCentral MessagePerspective

JTCVS Techniques, 2021
Objectives: There have been reports of postoperative conduction disturbances after rapid-deployment aortic valve replacement. Our objective was to assess electrocardiogram changes in patients undergoing this procedure and review the literature on this ...
Amalan Thuraisingam, MD, Andrew E. Newcomb, MBBS, FRACS   +1 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source