Results 41 to 50 of about 28,339 (262)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Generating Virtual Images from Oblique Frames

Remote Sensing, 2013
Image acquisition systems based on multi-head arrangement of digital cameras are attractive alternatives enabling a larger imaging area when compared to a single frame camera. The calibration of this kind of system can be performed in several steps or by
Carlos R. T. Caldeira, José Marcato, Marcus V. A. de Moraes, Mauricio Galo, Antonio M. G. Tommaselli, Rodrigo F. Lopes   +5 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Design and Test of a Traction Side-Pull Square Straw Bale Pick-Up-and-Stack Truck

Agriculture
To address the issues of limited one-time loading capacity, single functionality, and low automation level in existing square straw bale pickers, a large automated square straw bale pick-up-and-stack truck that integrates picking, stacking, transporting,
Yongli Zhao, Peisong Diao, Zetan Lu, Xianghao Li, Shaochuan Li, Shanshan Wang   +5 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Robust alternating optimisation for extrinsic calibration of RGB‐D cameras

Electronics Letters, 2019
RGB‐depth (RGB‐D) cameras are widely used for 3D reconstruction or human–computer interaction. To simultaneously acquire colour and depth images of an object in widely separated viewpoints, multiple RGB‐D cameras are required.
J.W. Jang, Y.C. Kwon, W. Hwang, O. Choi
doaj   +1 more source

Group actions, non-Kähler complex manifolds and SKT structures

Complex Manifolds, 2018
We give a construction of integrable complex structures on the total space of a smooth principal bundle over a complex manifold, with an even dimensional compact Lie group as structure group, under certain conditions.
Poddar Mainak, Thakur Ajay Singh
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Design and Implementation of 3D Reconstruction System Based on Monocular Vision [PDF]

Jisuanji gongcheng, 2018
Most of the visual reconstruction method have problems such as complicated equipment,low precision,and high time consuming.A three-dimensional model method for recovering a scene by a single handheld digital camera is proposed.The camera pose is ...
LLi,YAO Tuozhong,SONG Jiatao,XIAO Jiangjian,WANG Jianjun
doaj   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source