Results 51 to 60 of about 198,483 (281)
On the frame bundle adapted to a submanifold
, 2014 Let $M$ be a submanifold of a Riemannian manifold $(N,g)$. $M$ induces a subbundle $O(M,N)$ of adapted frames over $M$ of the bundle of orthonormal frames $O(N)$. Riemannian metric $g$ induces natural metric on $O(N)$.
Niedzialomski, Kamil
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Energy loss measurements of inclined muon bundles in the Cherenkov water detector [PDF]
EPJ Web of Conferences, 2019 An experiment on the measurements of the energy deposit of inclined cosmic ray muon bundles is being conducted at the experimental complex NEVOD (MEPhI).
Kokoulin R.P. +13 more
doaj +1 more source
On Imprisoned Curves and b-length in General Relativity [PDF]
, 2000 This paper is concerned with two themes: imprisoned curves and the b-length functional. In an earlier paper by the author, it was claimed that an endless incomplete curve partially imprisoned in a compact set admits an endless null geodesic cluster curve.
Ståhl, Fredrik
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Geometry of curves in parabolic homogeneous spaces
, 2013 The current paper is devoted to the study of integral curves of constant type in parabolic homogeneous spaces. We construct a canonical moving frame bundle for such curves and give the criterium when it turns out to be a Cartan connection ...
Doubrov, Boris, Zelenko, Igor
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Generating Virtual Images from Oblique Frames
Remote Sensing, 2013 Image acquisition systems based on multi-head arrangement of digital cameras are attractive alternatives enabling a larger imaging area when compared to a single frame camera. The calibration of this kind of system can be performed in several steps or by
Carlos R. T. Caldeira +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source