Results 51 to 60 of about 15,487 (310)

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Design of campus comprehensive access management platform

open access: yesTongxin xuebao, 2013
Considering access control with more card,scattered access flow data and poor scalabiliby in current unirersity building multi-system,the campus integrated access management platform triple frame design with the core of perception layer,transport layer ...
Cai-e XU   +4 more
doaj   +2 more sources

Research on characteristic model-based atmospheric duct interference control in TDD wireless communication system

open access: yesDianxin kexue, 2022
Atmospheric duct interference is a seriousinternal interference of large-scale TDD wireless communication system according to specific meteorological conditions.The causes and classification of the atmospheric duct interference were analyzed firstly.Then
Xiaoyun WANG   +4 more
doaj   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Framing labor contracts: Contract versus network theories [PDF]

open access: yesRecht der Werkelijkheid, 2016
‘Framing Labour Contracts: Contract versus Network Theories’ Since the 18th century the ‘contractual model’ has become both a paradigm of social theories (f.i. ‘rational choice’) and a dominant model of structuring labour relations. Its presupposition of the subjectivity of individual actors as a given is criticized with reference to network ...
openaire   +3 more sources

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah   +7 more
wiley   +1 more source

Practice of Connectivism As Learning Theory: Enhancing Learning Process Through Social Networking Site (Facebook)

open access: yesGaziantep Üniversitesi Sosyal Bilimler Dergisi, 2013
The impact of the digital age within learning and social interaction has been growing rapidly. The realm of digital age and computer mediated communication requires reconsidering instruction based on collaborative interactive learning process and socio ...
Fahriye Altınay Aksal   +2 more
doaj  

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