Results 91 to 100 of about 2,447,227 (317)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intervenir avec des masseurs-kinésithérapeutes : le développement en référence
Activités, 2013 The design of a profession’s standard frame of reference, for training or management purposes, has an effect on the activity of the persons involved in the process.
Stéphane Balas
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Consistency of shared reference frames should be reexamined
, 2008 In a recent Letter [G. Chiribella et al., Phys. Rev. Lett. 98, 120501 (2007)], four protocols were proposed to secretly transmit a reference frame. Here We point out that in these protocols an eavesdropper can change the transmitted reference frame ...
A. Wójcik +15 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Assistant without Master? Some Conceptual Implications of Assistive Robotics in Health Care
Technologies, 2018 The subject of “technical assistants” in inpatient care is currently being widely discussed in scientific and public circles. In many cases, though, it has become apparent that the umbrella term “assistive technologies”, also in the context of robotics ...
Bettina-Johanna Krings, Nora Weinberger
doaj +1 more source
The Absolute Frame of Reference [PDF]
The manuscript found the formula to calculate the real velocity of the earth and the maximum velocity in the universe, the values of the quantities after calculation as follows: V_earth = 1.852819296∗10^8 m/s.--
Khac Son, Ninh
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Informational Reinterpretation of the Mechanics Notions and Laws
Entropy, 2020 The informational re-interpretation of the basic laws of the mechanics exploiting the Landauer principle is suggested. When a physical body is in rest or it moves rectilinearly with the constant speed, zero information is transferred; thus, the ...
Edward Bormashenko
doaj +1 more source