Results 261 to 270 of about 2,188,737 (317)

A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper presents a microphysiological system containing an array of individually addressable living corneal tissues constructed using primary human cells. The bioengineered eye model can simulate acute exposure of the human cornea to different types of environmental toxicants and provides a novel platform for visualization and quantitative ...
Se‐jeong Kim   +12 more
wiley   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

open access: yesAdvanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia   +7 more
wiley   +1 more source

Graded Hydroxyapatite Triply Periodic Minimal Surface Structures for Bone Tissue Engineering Applications

open access: yesAdvanced Healthcare Materials, EarlyView.
This study investigates the role of triply periodic minimal structures in load bearing bone tissue engineering applications. Research uses a combination of mechanical testing, material characterization, and in vitro tests to study the impact of TPMS lattice structures (gyroid, lidinoid and split‐P).
Tejas M. Koushik   +2 more
wiley   +1 more source

Bioprinted Micro‐Clots for Kinetic Analysis of Endothelial Cell‐Mediated Fibrinolysis

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This paper describes the development of a microscale model that quantifies the breakdown of fibrin by endothelial cells. The small size scale of this engineered system enables fibrin breakdown to be observed without the addition of external activators. This system could help in identifying compounds which both promote and hinder thrombosis.
Jonathan J. Chang   +5 more
wiley   +1 more source

Kidney Stone Dissolution By Tetherless, Enzyme‐Loaded, Soft Magnetic Miniature Robots

open access: yesAdvanced Healthcare Materials, EarlyView.
Wireless magnetic robots are developed for kidney stone dissolution. The robots navigate through a urinary tract model from bladder and ureter to renal pelvis with the help of external magnetic fields. The filaments are loaded with urease enzyme which catalyzes urea to carbon dioxide and ammonia, thereby increasing pH to basic regime and supporting ...
Afarin Khabbazian   +15 more
wiley   +1 more source

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