Results 71 to 80 of about 761,503 (219)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Fast inter-frame motion correction in contrast-free ultrasound quantitative microvasculature imaging using deep learning

Scientific Reports
Contrast-free ultrasound quantitative microvasculature imaging shows promise in several applications, including the assessment of benign and malignant lesions. However, motion represents one of the major challenges in imaging tumor microvessels in organs
Manali Saini, Mostafa Fatemi, Azra Alizad   +2 more
doaj   +1 more source

Threat to freedom and the detrimental effect of avoidance goal frames: Reactance as a mediating variable

Frontiers in Psychology, 2016
Two experiments examined how individuals respond to a restriction presented within an approach versus an avoidance frame. In Study 1, working on a problem-solving task, participants were initially free to choose their strategy, but for a second task were
Daniela Niesta Kayser, Verena Graupmann, James W. Fryer, Dieter Frey   +3 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

EFSP-TE: End-to-End Frame-Semantic Parsing with Table Encoder

Tsinghua Science and Technology
Frame-Semantic Parsing (FSP) aims to extract frame-semantic structures from text. The task usually involves three subtasks sequentially: Target Identification (TI), Frame Identification (FI), and Frame Semantic Role Labeling (FSRL).
Xuefeng Su, Ru Li, Xiaoli Li, Zhichao Yan   +3 more
doaj   +1 more source

Periodic orbits of the generalized Friedmann-Robertson-Walker potential in galactic dynamics in a rotating reference frame

AIP Advances, 2017
In this work, we study analytically the existence of periodic solution for Friedmann- Robertson-Walker Hamiltonian systems in a rotating frame using average theory of first order. The stability of these periodic solutions is investigated.
M. M. El-Dessoky, A. A. Elmandouh, Aatef Hobiny   +2 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Quantum and classical dynamics comparison: A way for selecting the vector potential across diverse frames

Heliyon
This study explores the quantum dynamics of a free electron subjected to an intense laser field, considering various gauges within and beyond the dipole approximation.
Maryam Pakpour, Amir H. Darooneh, Mohammad Mahmoudi   +2 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source