Results 51 to 60 of about 575,425 (313)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Total extraperitoneal approach in large inguino-scrotal hernias: an institutional approach
Journal of Society of Surgeons of Nepal, 2016 Introduction: Since 2 decades laparoscopichernia repair has gained key role in uncomplicated inguinal hernia surgery with advantages showed by several trials and guidelines.
Tuhin Shah +4 more
doaj +1 more source
A Ray-Tracing Model of the Vela Pulsar [PDF]
, 2001 In the relativistic plasma surrounding a pulsar, a subluminal ordinary-mode electromagnetic wave will propagate along a magnetic field line. After some distance, it can break free of the field line and escape the magnetosphere to reach an observer.
C. Hirano +3 more
core +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Land use inventory as framework for environmental accounting: an application in Italy
iForest - Biogeosciences and Forestry, 2012 Land use inventories are sound measures to provide information on the area occupied by different land use or land cover types and their changes, although less widespread than traditional mapping; as such, they are distinctively well-established tools for
Corona P +7 more
doaj +1 more source
PHIBSS: molecular gas content and scaling relations in z~1-3 normal star forming galaxies
, 2012 We present PHIBSS, the IRAM Plateau de Bure high-z blue sequence CO 3-2 survey of the molecular gas properties in normal star forming galaxies (SFGs) near the cosmic star formation peak.
Bolatto, A. +23 more
core +3 more sources
Wavelength conversion at 10 Gb/s by four-wave mixing over a 30-nm interval [PDF]
, 1998 We show that the use of a long semiconductor optical amplifier increases the error-free conversion interval of a four-wave mixing (FWM)-based wavelength converter.
D'Ottavi, A. +6 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
The Pan African Medical Journal, 2014 INTRODUCTION: Tuberculosis (TB) is public health concern in Nigeria. The country uses the Directly Observed Treatment Short course (DOTS) strategy for its control.
Luka Mangveep Ibrahim +7 more
doaj +1 more source